Recognition Properties of Cucurbit[7]uril Self-Assembled Monolayers Studied with Force Spectroscopy

A. Gomez Casado; Pascal Jonkheijm; Jurriaan Huskens

doi:10.1021/la202346r

Recognition Properties of Cucurbit[7]uril Self-Assembled Monolayers Studied with Force Spectroscopy

A. Gomez Casado, Pascal Jonkheijm, Jurriaan Huskens

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Abstract

Specific (host–guest) and unspecific (substrate–guest) interactions between self-assembled monolayers of cucurbit[7]uril (CB[7]) on gold (Au) substrates and neutral adamantyl (Ad) guests were resolved by studying these interactions at the single molecule level using dynamic force spectroscopy. The dissociation rate constants of the Ad–Au and the Ad–CB[7] interactions were 0.3 s–1 and 0.03 s–1, respectively, indicating that the specific binding is more stable. The probability of observing a specific interaction (40 ± 9%) is similar to the reported surface coverages of CB[7] monolayers on Au substrates. The higher strength and stability of the Ad–CB[7] interactions explains why, although presenting an imperfect coverage, CB[n] monolayers can be used successfully as a platform for surface immobilization.

Original language	English
Pages (from-to)	11508-11513
Number of pages	6
Journal	Langmuir
Volume	27
Issue number	18
DOIs	https://doi.org/10.1021/la202346r
Publication status	Published - 2011

Keywords

METIS-282324
IR-104544

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title = "Recognition Properties of Cucurbit[7]uril Self-Assembled Monolayers Studied with Force Spectroscopy",

abstract = "Specific (host–guest) and unspecific (substrate–guest) interactions between self-assembled monolayers of cucurbit[7]uril (CB[7]) on gold (Au) substrates and neutral adamantyl (Ad) guests were resolved by studying these interactions at the single molecule level using dynamic force spectroscopy. The dissociation rate constants of the Ad–Au and the Ad–CB[7] interactions were 0.3 s–1 and 0.03 s–1, respectively, indicating that the specific binding is more stable. The probability of observing a specific interaction (40 ± 9%) is similar to the reported surface coverages of CB[7] monolayers on Au substrates. The higher strength and stability of the Ad–CB[7] interactions explains why, although presenting an imperfect coverage, CB[n] monolayers can be used successfully as a platform for surface immobilization.",

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author = "{Gomez Casado}, A. and Pascal Jonkheijm and Jurriaan Huskens",

year = "2011",

doi = "10.1021/la202346r",

language = "English",

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journal = "Langmuir",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Recognition Properties of Cucurbit[7]uril Self-Assembled Monolayers Studied with Force Spectroscopy

AU - Gomez Casado, A.

AU - Jonkheijm, Pascal

AU - Huskens, Jurriaan

PY - 2011

Y1 - 2011

N2 - Specific (host–guest) and unspecific (substrate–guest) interactions between self-assembled monolayers of cucurbit[7]uril (CB[7]) on gold (Au) substrates and neutral adamantyl (Ad) guests were resolved by studying these interactions at the single molecule level using dynamic force spectroscopy. The dissociation rate constants of the Ad–Au and the Ad–CB[7] interactions were 0.3 s–1 and 0.03 s–1, respectively, indicating that the specific binding is more stable. The probability of observing a specific interaction (40 ± 9%) is similar to the reported surface coverages of CB[7] monolayers on Au substrates. The higher strength and stability of the Ad–CB[7] interactions explains why, although presenting an imperfect coverage, CB[n] monolayers can be used successfully as a platform for surface immobilization.

AB - Specific (host–guest) and unspecific (substrate–guest) interactions between self-assembled monolayers of cucurbit[7]uril (CB[7]) on gold (Au) substrates and neutral adamantyl (Ad) guests were resolved by studying these interactions at the single molecule level using dynamic force spectroscopy. The dissociation rate constants of the Ad–Au and the Ad–CB[7] interactions were 0.3 s–1 and 0.03 s–1, respectively, indicating that the specific binding is more stable. The probability of observing a specific interaction (40 ± 9%) is similar to the reported surface coverages of CB[7] monolayers on Au substrates. The higher strength and stability of the Ad–CB[7] interactions explains why, although presenting an imperfect coverage, CB[n] monolayers can be used successfully as a platform for surface immobilization.

KW - METIS-282324

KW - IR-104544

U2 - 10.1021/la202346r

DO - 10.1021/la202346r

M3 - Article

SN - 0743-7463

VL - 27

SP - 11508

EP - 11513

JO - Langmuir

JF - Langmuir

IS - 18

ER -

Recognition Properties of Cucurbit[7]uril Self-Assembled Monolayers Studied with Force Spectroscopy

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