Recognition Properties of Cucurbit[7]uril Self-Assembled Monolayers Studied with Force Spectroscopy

A. Gomez Casado, Pascal Jonkheijm, Jurriaan Huskens

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Specific (host–guest) and unspecific (substrate–guest) interactions between self-assembled monolayers of cucurbit[7]uril (CB[7]) on gold (Au) substrates and neutral adamantyl (Ad) guests were resolved by studying these interactions at the single molecule level using dynamic force spectroscopy. The dissociation rate constants of the Ad–Au and the Ad–CB[7] interactions were 0.3 s–1 and 0.03 s–1, respectively, indicating that the specific binding is more stable. The probability of observing a specific interaction (40 ± 9%) is similar to the reported surface coverages of CB[7] monolayers on Au substrates. The higher strength and stability of the Ad–CB[7] interactions explains why, although presenting an imperfect coverage, CB[n] monolayers can be used successfully as a platform for surface immobilization.
Original languageEnglish
Pages (from-to)11508-11513
Number of pages6
Issue number18
Publication statusPublished - 2011


  • METIS-282324
  • IR-104544


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