Recruitment to and pilot results of the PACES randomized trial of physical exercise during adjuvant chemotherapy for colon cancer

Hanna van Waart, Martijn M. Stuiver, Willem H. van Harten, Edwin Geleijn, Marianne de Maaker-Berkhof, Jolanda Schrama, Maud M. Geenen, Jetkse M. Meerum Terwogt, Simone M. van den Heiligenberg, Jeannette A.J.H. Hellendoorn-van Vreeswijk, Gabe S. Sonke, Neil K. Aaronson (Corresponding Author)

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Abstract

We report the recruitment rate, reasons for and factors influencing non-participation, and descriptive results of a randomized controlled trial of two different exercise programs for patients with colon cancer undergoing adjuvant chemotherapy.
Participants were randomized to a low-intensity, home-based program (Onco-Move), a moderate- to high-intensity, combined supervised resistance and aerobic exercise program (OnTrack), or Usual Care. Non-participants provided reasons for non-participation and were asked to complete a questionnaire assessing behavioral and attitudinal variables. Trial participants completed performance-based and self-reported outcome measures prior to randomization, at the end of chemotherapy, and at the 6-month follow-up. Twenty-three of 63 referred patients agreed to participate in the trial. All 40 non-participants provided reasons for non-participation. Forty-five percent of the non-participants completed the questionnaire. Those who did not want to exercise had higher fatigue scores at baseline and a more negative attitude toward exercise. Compliance to both programs was high and no adverse events occurred. On average, the colon cancer participants were able to maintain or improve their physical fitness levels and maintain or decrease their fatigue levels during chemotherapy and follow-up.
Recruitment of patients with colon cancer to a physical exercise trial during adjuvant chemotherapy proved to be difficult, underscoring the need to develop more effective strategies to increase participation rates. Both home-based and supervised programs are safe and feasible in patients with colon cancer undergoing chemotherapy. Effectiveness needs to be established in a larger trial.
Original languageEnglish
Pages (from-to)29-40
JournalInternational journal of colorectal disease
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 2018

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Adjuvant Chemotherapy
Colonic Neoplasms
Exercise
Drug Therapy
Fatigue
Physical Fitness
Random Allocation
Patient Selection
Compliance
Randomized Controlled Trials
Outcome Assessment (Health Care)
Surveys and Questionnaires

Keywords

  • UT-Hybrid-D

Cite this

van Waart, Hanna ; Stuiver, Martijn M. ; van Harten, Willem H. ; Geleijn, Edwin ; de Maaker-Berkhof, Marianne ; Schrama, Jolanda ; Geenen, Maud M. ; Meerum Terwogt, Jetkse M. ; van den Heiligenberg, Simone M. ; Hellendoorn-van Vreeswijk, Jeannette A.J.H. ; Sonke, Gabe S. ; Aaronson, Neil K. / Recruitment to and pilot results of the PACES randomized trial of physical exercise during adjuvant chemotherapy for colon cancer. In: International journal of colorectal disease. 2018 ; Vol. 33, No. 1. pp. 29-40.
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abstract = "We report the recruitment rate, reasons for and factors influencing non-participation, and descriptive results of a randomized controlled trial of two different exercise programs for patients with colon cancer undergoing adjuvant chemotherapy.Participants were randomized to a low-intensity, home-based program (Onco-Move), a moderate- to high-intensity, combined supervised resistance and aerobic exercise program (OnTrack), or Usual Care. Non-participants provided reasons for non-participation and were asked to complete a questionnaire assessing behavioral and attitudinal variables. Trial participants completed performance-based and self-reported outcome measures prior to randomization, at the end of chemotherapy, and at the 6-month follow-up. Twenty-three of 63 referred patients agreed to participate in the trial. All 40 non-participants provided reasons for non-participation. Forty-five percent of the non-participants completed the questionnaire. Those who did not want to exercise had higher fatigue scores at baseline and a more negative attitude toward exercise. Compliance to both programs was high and no adverse events occurred. On average, the colon cancer participants were able to maintain or improve their physical fitness levels and maintain or decrease their fatigue levels during chemotherapy and follow-up.Recruitment of patients with colon cancer to a physical exercise trial during adjuvant chemotherapy proved to be difficult, underscoring the need to develop more effective strategies to increase participation rates. Both home-based and supervised programs are safe and feasible in patients with colon cancer undergoing chemotherapy. Effectiveness needs to be established in a larger trial.",
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van Waart, H, Stuiver, MM, van Harten, WH, Geleijn, E, de Maaker-Berkhof, M, Schrama, J, Geenen, MM, Meerum Terwogt, JM, van den Heiligenberg, SM, Hellendoorn-van Vreeswijk, JAJH, Sonke, GS & Aaronson, NK 2018, 'Recruitment to and pilot results of the PACES randomized trial of physical exercise during adjuvant chemotherapy for colon cancer', International journal of colorectal disease, vol. 33, no. 1, pp. 29-40. https://doi.org/10.1007/s00384-017-2921-6

Recruitment to and pilot results of the PACES randomized trial of physical exercise during adjuvant chemotherapy for colon cancer. / van Waart, Hanna; Stuiver, Martijn M.; van Harten, Willem H.; Geleijn, Edwin; de Maaker-Berkhof, Marianne; Schrama, Jolanda; Geenen, Maud M.; Meerum Terwogt, Jetkse M.; van den Heiligenberg, Simone M.; Hellendoorn-van Vreeswijk, Jeannette A.J.H.; Sonke, Gabe S.; Aaronson, Neil K. (Corresponding Author).

In: International journal of colorectal disease, Vol. 33, No. 1, 01.2018, p. 29-40.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Recruitment to and pilot results of the PACES randomized trial of physical exercise during adjuvant chemotherapy for colon cancer

AU - van Waart, Hanna

AU - Stuiver, Martijn M.

AU - van Harten, Willem H.

AU - Geleijn, Edwin

AU - de Maaker-Berkhof, Marianne

AU - Schrama, Jolanda

AU - Geenen, Maud M.

AU - Meerum Terwogt, Jetkse M.

AU - van den Heiligenberg, Simone M.

AU - Hellendoorn-van Vreeswijk, Jeannette A.J.H.

AU - Sonke, Gabe S.

AU - Aaronson, Neil K.

N1 - Springer deal

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N2 - We report the recruitment rate, reasons for and factors influencing non-participation, and descriptive results of a randomized controlled trial of two different exercise programs for patients with colon cancer undergoing adjuvant chemotherapy.Participants were randomized to a low-intensity, home-based program (Onco-Move), a moderate- to high-intensity, combined supervised resistance and aerobic exercise program (OnTrack), or Usual Care. Non-participants provided reasons for non-participation and were asked to complete a questionnaire assessing behavioral and attitudinal variables. Trial participants completed performance-based and self-reported outcome measures prior to randomization, at the end of chemotherapy, and at the 6-month follow-up. Twenty-three of 63 referred patients agreed to participate in the trial. All 40 non-participants provided reasons for non-participation. Forty-five percent of the non-participants completed the questionnaire. Those who did not want to exercise had higher fatigue scores at baseline and a more negative attitude toward exercise. Compliance to both programs was high and no adverse events occurred. On average, the colon cancer participants were able to maintain or improve their physical fitness levels and maintain or decrease their fatigue levels during chemotherapy and follow-up.Recruitment of patients with colon cancer to a physical exercise trial during adjuvant chemotherapy proved to be difficult, underscoring the need to develop more effective strategies to increase participation rates. Both home-based and supervised programs are safe and feasible in patients with colon cancer undergoing chemotherapy. Effectiveness needs to be established in a larger trial.

AB - We report the recruitment rate, reasons for and factors influencing non-participation, and descriptive results of a randomized controlled trial of two different exercise programs for patients with colon cancer undergoing adjuvant chemotherapy.Participants were randomized to a low-intensity, home-based program (Onco-Move), a moderate- to high-intensity, combined supervised resistance and aerobic exercise program (OnTrack), or Usual Care. Non-participants provided reasons for non-participation and were asked to complete a questionnaire assessing behavioral and attitudinal variables. Trial participants completed performance-based and self-reported outcome measures prior to randomization, at the end of chemotherapy, and at the 6-month follow-up. Twenty-three of 63 referred patients agreed to participate in the trial. All 40 non-participants provided reasons for non-participation. Forty-five percent of the non-participants completed the questionnaire. Those who did not want to exercise had higher fatigue scores at baseline and a more negative attitude toward exercise. Compliance to both programs was high and no adverse events occurred. On average, the colon cancer participants were able to maintain or improve their physical fitness levels and maintain or decrease their fatigue levels during chemotherapy and follow-up.Recruitment of patients with colon cancer to a physical exercise trial during adjuvant chemotherapy proved to be difficult, underscoring the need to develop more effective strategies to increase participation rates. Both home-based and supervised programs are safe and feasible in patients with colon cancer undergoing chemotherapy. Effectiveness needs to be established in a larger trial.

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