Redox cycling in nanofluidic channels using interdigitated electrodes

Edgar D. Goluch, Bernhard Wolfrum, Pradyumna S. Singh, Marcel A.G. Zevenbergen, Serge G. Lemay*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

89 Citations (Scopus)


Amperometric detection is ideally suited for integration into micro- and nanofluidic systems as it directly yields an electrical signal and does not necessitate optical components. However, the range of systems to which it can be applied is constrained by the limited sensitivity and specificity of the method. These limitations can be partially alleviated through the use of redox cycling, in which multiple electrodes are employed to repeatedly reduce and oxidize analyte molecules and thereby amplify the detected signal. We have developed an interdigitated electrode device that is encased in a nanofluidic channel to provide a hundred-fold amplification of the amperometric signal from paracetamol. Due to the nanochannel design, the sensor is resistant to interference from molecules undergoing irreversible redox reactions. We demonstrate this selectivity by detecting paracetamol in the presence of excess ascorbic acid.

Original languageEnglish
Pages (from-to)447-456
Number of pages10
JournalAnalytical and bioanalytical chemistry
Issue number2
Publication statusPublished - May 2009
Externally publishedYes


  • Amperometric detection
  • Ascorbic acid
  • Electrochemistry
  • Interdigitated electrodes (IDEs)
  • Nanofluidic
  • Nanotechnology
  • Paracetamol
  • Redox cycling
  • Sensor


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