Reduction of Taylor-Aris dispersion by lateral mixing for chromatographic applications

Eiko Y. Westerbeek, Johan G. Bomer, Wouter Olthuis, Jan C.T. Eijkel, Wim De Malsche*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
159 Downloads (Pure)


Chromatographic columns are suffering from Taylor-Aris dispersion, especially for slowly diffusing molecules such as proteins. Since downscaling the channel size to reduce Taylor-Aris dispersion meets fundamental pressure limitations, new strategies are needed to further improve chromatography beyond its current limits. In this work we demonstrate a method to reduce Taylor-Aris dispersion by lateral mixing in a newly designed silicon AC-electroosmotic flow mixer. We obtained a reduction in κaris by a factor of three in a 40 μm × 20 μm microchannel, corresponding to a plate height gain of 2 to 3 under unretained conditions at low to high Pe values. We also demonstrate an improvement of a reverse-phase chromatographic separation of coumarins.

Original languageEnglish
Pages (from-to)3938-3947
Number of pages10
JournalLab on a chip
Issue number21
Publication statusPublished - 7 Nov 2020


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