Regenerative electronic biosensors using supramolecular approaches

X. Duan, N. Rajan, D. Routenberg, Jurriaan Huskens, M. Reed

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)


A supramolecular interface for Si nanowire FETs has been developed with the aim of creating regenerative electronic biosensors. The key to the approach is Si-NWs functionalized with β-cyclodextrin (β-CD), to which receptor moieties can be attached with an orthogonal supramolecular linker. Here we demonstrate full recycling using the strongest biomolecular system known, streptavidin (SAv)–biotin. The bound SAv and the linkers can be selectively removed from the surface through competitive desorption with concentrated β-CD, regenerating the sensor for repeated use. An added advantage of β-CD is the possibility of stereoselective sensors, and we demonstrate here the ability to quantify the enantiomeric composition of chiral targets
Original languageEnglish
Pages (from-to)4014-4021
Number of pages7
JournalACS nano
Issue number5
Publication statusPublished - 2013


  • METIS-301573
  • IR-90123


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