Relation Between Plaque Progression and Low-Density Lipoprotein Cholesterol During Aging as Assessed With Serial Long-Term (≥12 Months) Follow-Up Intravascular Ultrasound of the Left Main Coronary Artery

Marc Hartmann, Clemens von Birgelen* (Corresponding Author), Gary S. Mintz, Gert K. van Houwelingen, Holger Eggebrecht, Dirk Böse, Heinrich Wieneke, Patrick M J Verhorst, Raimund Erbel

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    10 Citations (Scopus)

    Abstract

    Because of the clinical benefit of lipid lowering in older patients, we hypothesized that the relation between low-density lipoprotein (LDL) cholesterol serum levels and coronary plaque progression may persist throughout aging. We analyzed serial intravascular ultrasound (IVUS) data of 60 left main stems (18 ± 9 months apart) and evaluated the relation between LDL cholesterol levels and coronary plaque progression at different ages. The population (n = 60) was divided into 3 groups according to age: tertile 1 (n = 20) was a mean age of 48 ± 6 years (median 51, range 33 to 55), tertile 2 (n = 20) was a mean age of 58 ± 2 years (median 59, range 55 to 61), and tertile 3 (n = 20) was a mean age of 66 ± 6 years (median 65, range 61 to 83). Between groups, there was no significant difference in non-age-related demographics, clinical data, lipid profiles, or medications (e.g., statins). There was a positive linear relation between LDL cholesterol and annual changes in plaque plus media area in all age tertiles, which was statistically significant in tertiles 2 and 3 (r = 0.56, p <0.01; r = 0.50, p <0.02) and showed a strong trend in tertile 1 (r = 0.41, p = 0.07). The estimated LDL cholesterol thresholds, which, as determined by regression analysis, would correspond to no plaque progression, were 74, 60, and 78 mg/dl, respectively, in tertiles 1, 2, and 3. In conclusion, serial IVUS data in left main coronary arteries suggest that the relation between LDL cholesterol serum levels and plaque progression persists during aging.

    Original languageEnglish
    Pages (from-to)1419-1423
    Number of pages5
    JournalAmerican journal of cardiology
    Volume98
    Issue number11
    DOIs
    Publication statusPublished - 1 Dec 2006

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