Abstract
| Original language | Undefined |
|---|---|
| Pages (from-to) | 72-85 |
| Number of pages | 14 |
| Journal | Biomedical optics express |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 |
Keywords
- METIS-310505
- IR-96026
Cite this
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Relation between speckle decorrelation and optical phase conjugation (OPC)- based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin. / Jang, Mooseok; Ruan, Haowen; Vellekoop, Ivo Micha; Judkewitz, Benjamin; Chung, Euiheon; Yang, Changhuei.
In: Biomedical optics express, Vol. 6, No. 1, 2015, p. 72-85.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Relation between speckle decorrelation and optical phase conjugation (OPC)- based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin
AU - Jang, Mooseok
AU - Ruan, Haowen
AU - Vellekoop, Ivo Micha
AU - Judkewitz, Benjamin
AU - Chung, Euiheon
AU - Yang, Changhuei
N1 - Open access
PY - 2015
Y1 - 2015
N2 - Light scattering in biological tissue significantly limits the accessible depth for localized optical interrogation and deep-tissue optical imaging. This challenge can be overcome by exploiting the time-reversal property of optical phase conjugation (OPC) to reverse multiple scattering events or suppress turbidity. However, in living tissue, scatterers are highly movable and the movement can disrupt time-reversal symmetry when there is a latency in the OPC playback. In this paper, we show that the motion-induced degradation of the OPC turbidity-suppression effect through a dynamic scattering medium shares the same decorrelation time constant as that determined from speckle intensity autocorrelation – a popular conventional measure of scatterer movement. We investigated this decorrelation characteristic time through a 1.5-mm-thick dorsal skin flap of a living mouse and found that it ranges from 50 ms to 2.5 s depending on the level of immobilization. This study provides information on relevant time scales for applying OPC to living tissues
AB - Light scattering in biological tissue significantly limits the accessible depth for localized optical interrogation and deep-tissue optical imaging. This challenge can be overcome by exploiting the time-reversal property of optical phase conjugation (OPC) to reverse multiple scattering events or suppress turbidity. However, in living tissue, scatterers are highly movable and the movement can disrupt time-reversal symmetry when there is a latency in the OPC playback. In this paper, we show that the motion-induced degradation of the OPC turbidity-suppression effect through a dynamic scattering medium shares the same decorrelation time constant as that determined from speckle intensity autocorrelation – a popular conventional measure of scatterer movement. We investigated this decorrelation characteristic time through a 1.5-mm-thick dorsal skin flap of a living mouse and found that it ranges from 50 ms to 2.5 s depending on the level of immobilization. This study provides information on relevant time scales for applying OPC to living tissues
KW - METIS-310505
KW - IR-96026
U2 - 10.1364/BOE.6.000072
DO - 10.1364/BOE.6.000072
M3 - Article
VL - 6
SP - 72
EP - 85
JO - Biomedical optics express
JF - Biomedical optics express
SN - 2156-7085
IS - 1
ER -