Relation between speckle decorrelation and optical phase conjugation (OPC)- based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin

Mooseok Jang, Haowen Ruan, Ivo Micha Vellekoop, Benjamin Judkewitz, Euiheon Chung, Changhuei Yang

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Abstract

Light scattering in biological tissue significantly limits the accessible depth for localized optical interrogation and deep-tissue optical imaging. This challenge can be overcome by exploiting the time-reversal property of optical phase conjugation (OPC) to reverse multiple scattering events or suppress turbidity. However, in living tissue, scatterers are highly movable and the movement can disrupt time-reversal symmetry when there is a latency in the OPC playback. In this paper, we show that the motion-induced degradation of the OPC turbidity-suppression effect through a dynamic scattering medium shares the same decorrelation time constant as that determined from speckle intensity autocorrelation – a popular conventional measure of scatterer movement. We investigated this decorrelation characteristic time through a 1.5-mm-thick dorsal skin flap of a living mouse and found that it ranges from 50 ms to 2.5 s depending on the level of immobilization. This study provides information on relevant time scales for applying OPC to living tissues
Original languageUndefined
Pages (from-to)72-85
Number of pages14
JournalBiomedical optics express
Volume6
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • METIS-310505
  • IR-96026

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