Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients

Ben Bulten, H.J. Verberne, L. Bellersen, W.J. Oyen, A. Sabate-Llobera, A.M. Mavinkurve-Groothuis, L. Kapusta, H.W. van Laarhoven, Lioe-Fee de Geus-Oei

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Abstract

Purpose It remains challenging to identify patients at risk of anthracycline-induced cardiotoxicity. To better understand the different risk-stratifying approaches, we evaluated 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy and its interrelationship with conventional echocardiography, 2D strain imaging and several biomarkers. Methods We performed 123I-mIBG scintigraphy, conventional and strain echocardiography and biomarker (NT-proBNP, TNF-α, galectin-3, IL-6, troponin I, ST-2 and sFlt-1) assessment in 59 breast cancer survivors 1 year after anthracycline treatment. Interobserver and intermethod variability was calculated on planar and SPECT 123I-mIBG scintigraphy, using the heart/mediastinum (H/M) ratio and washout (WO). Pearson’s r and multivariate analyses were performed to identify correlations and independent predictors of 123I-mIBG scintigraphy results. Results Delayed planar anterior whole-heart ROI (WH) H/M ratios and WO were the most robust 123I-mIBG parameters. Significant correlations were observed between 123I-mIBG parameters and several conventional echo parameters, global longitudinal and radial strain (GLS and GRS) and galectin-3. The highest Pearson’s r was observed between delayed H/M ratio and GRS (Pearson’s r 0.36, p = 0.01). Multivariate analysis showed that GRS was the only independent predictor of the delayed WH H/M ratio (p = 0.023). Conclusion The delayed planar H/M ratio is the most robust 123I-mIBG parameter. It correlates with several conventional echocardiographic parameters, GLS, GRS and galectin-3. Of these, only GRS predicts the H/M ratio.
Original languageUndefined
Pages (from-to)957-967
Number of pages11
JournalCancer chemotherapy and pharmacology
Volume76
Issue number5
DOIs
Publication statusPublished - 2015

Keywords

  • METIS-313399
  • IR-99830

Cite this

Bulten, Ben ; Verberne, H.J. ; Bellersen, L. ; Oyen, W.J. ; Sabate-Llobera, A. ; Mavinkurve-Groothuis, A.M. ; Kapusta, L. ; van Laarhoven, H.W. ; de Geus-Oei, Lioe-Fee. / Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients. In: Cancer chemotherapy and pharmacology. 2015 ; Vol. 76, No. 5. pp. 957-967.
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title = "Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients",
abstract = "Purpose It remains challenging to identify patients at risk of anthracycline-induced cardiotoxicity. To better understand the different risk-stratifying approaches, we evaluated 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy and its interrelationship with conventional echocardiography, 2D strain imaging and several biomarkers. Methods We performed 123I-mIBG scintigraphy, conventional and strain echocardiography and biomarker (NT-proBNP, TNF-α, galectin-3, IL-6, troponin I, ST-2 and sFlt-1) assessment in 59 breast cancer survivors 1 year after anthracycline treatment. Interobserver and intermethod variability was calculated on planar and SPECT 123I-mIBG scintigraphy, using the heart/mediastinum (H/M) ratio and washout (WO). Pearson’s r and multivariate analyses were performed to identify correlations and independent predictors of 123I-mIBG scintigraphy results. Results Delayed planar anterior whole-heart ROI (WH) H/M ratios and WO were the most robust 123I-mIBG parameters. Significant correlations were observed between 123I-mIBG parameters and several conventional echo parameters, global longitudinal and radial strain (GLS and GRS) and galectin-3. The highest Pearson’s r was observed between delayed H/M ratio and GRS (Pearson’s r 0.36, p = 0.01). Multivariate analysis showed that GRS was the only independent predictor of the delayed WH H/M ratio (p = 0.023). Conclusion The delayed planar H/M ratio is the most robust 123I-mIBG parameter. It correlates with several conventional echocardiographic parameters, GLS, GRS and galectin-3. Of these, only GRS predicts the H/M ratio.",
keywords = "METIS-313399, IR-99830",
author = "Ben Bulten and H.J. Verberne and L. Bellersen and W.J. Oyen and A. Sabate-Llobera and A.M. Mavinkurve-Groothuis and L. Kapusta and {van Laarhoven}, H.W. and {de Geus-Oei}, Lioe-Fee",
year = "2015",
doi = "10.1007/s00280-015-2874-9",
language = "Undefined",
volume = "76",
pages = "957--967",
journal = "Cancer chemotherapy and pharmacology",
issn = "0344-5704",
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number = "5",

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Bulten, B, Verberne, HJ, Bellersen, L, Oyen, WJ, Sabate-Llobera, A, Mavinkurve-Groothuis, AM, Kapusta, L, van Laarhoven, HW & de Geus-Oei, L-F 2015, 'Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients', Cancer chemotherapy and pharmacology, vol. 76, no. 5, pp. 957-967. https://doi.org/10.1007/s00280-015-2874-9

Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients. / Bulten, Ben; Verberne, H.J.; Bellersen, L.; Oyen, W.J.; Sabate-Llobera, A.; Mavinkurve-Groothuis, A.M.; Kapusta, L.; van Laarhoven, H.W.; de Geus-Oei, Lioe-Fee.

In: Cancer chemotherapy and pharmacology, Vol. 76, No. 5, 2015, p. 957-967.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients

AU - Bulten, Ben

AU - Verberne, H.J.

AU - Bellersen, L.

AU - Oyen, W.J.

AU - Sabate-Llobera, A.

AU - Mavinkurve-Groothuis, A.M.

AU - Kapusta, L.

AU - van Laarhoven, H.W.

AU - de Geus-Oei, Lioe-Fee

PY - 2015

Y1 - 2015

N2 - Purpose It remains challenging to identify patients at risk of anthracycline-induced cardiotoxicity. To better understand the different risk-stratifying approaches, we evaluated 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy and its interrelationship with conventional echocardiography, 2D strain imaging and several biomarkers. Methods We performed 123I-mIBG scintigraphy, conventional and strain echocardiography and biomarker (NT-proBNP, TNF-α, galectin-3, IL-6, troponin I, ST-2 and sFlt-1) assessment in 59 breast cancer survivors 1 year after anthracycline treatment. Interobserver and intermethod variability was calculated on planar and SPECT 123I-mIBG scintigraphy, using the heart/mediastinum (H/M) ratio and washout (WO). Pearson’s r and multivariate analyses were performed to identify correlations and independent predictors of 123I-mIBG scintigraphy results. Results Delayed planar anterior whole-heart ROI (WH) H/M ratios and WO were the most robust 123I-mIBG parameters. Significant correlations were observed between 123I-mIBG parameters and several conventional echo parameters, global longitudinal and radial strain (GLS and GRS) and galectin-3. The highest Pearson’s r was observed between delayed H/M ratio and GRS (Pearson’s r 0.36, p = 0.01). Multivariate analysis showed that GRS was the only independent predictor of the delayed WH H/M ratio (p = 0.023). Conclusion The delayed planar H/M ratio is the most robust 123I-mIBG parameter. It correlates with several conventional echocardiographic parameters, GLS, GRS and galectin-3. Of these, only GRS predicts the H/M ratio.

AB - Purpose It remains challenging to identify patients at risk of anthracycline-induced cardiotoxicity. To better understand the different risk-stratifying approaches, we evaluated 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy and its interrelationship with conventional echocardiography, 2D strain imaging and several biomarkers. Methods We performed 123I-mIBG scintigraphy, conventional and strain echocardiography and biomarker (NT-proBNP, TNF-α, galectin-3, IL-6, troponin I, ST-2 and sFlt-1) assessment in 59 breast cancer survivors 1 year after anthracycline treatment. Interobserver and intermethod variability was calculated on planar and SPECT 123I-mIBG scintigraphy, using the heart/mediastinum (H/M) ratio and washout (WO). Pearson’s r and multivariate analyses were performed to identify correlations and independent predictors of 123I-mIBG scintigraphy results. Results Delayed planar anterior whole-heart ROI (WH) H/M ratios and WO were the most robust 123I-mIBG parameters. Significant correlations were observed between 123I-mIBG parameters and several conventional echo parameters, global longitudinal and radial strain (GLS and GRS) and galectin-3. The highest Pearson’s r was observed between delayed H/M ratio and GRS (Pearson’s r 0.36, p = 0.01). Multivariate analysis showed that GRS was the only independent predictor of the delayed WH H/M ratio (p = 0.023). Conclusion The delayed planar H/M ratio is the most robust 123I-mIBG parameter. It correlates with several conventional echocardiographic parameters, GLS, GRS and galectin-3. Of these, only GRS predicts the H/M ratio.

KW - METIS-313399

KW - IR-99830

U2 - 10.1007/s00280-015-2874-9

DO - 10.1007/s00280-015-2874-9

M3 - Article

VL - 76

SP - 957

EP - 967

JO - Cancer chemotherapy and pharmacology

JF - Cancer chemotherapy and pharmacology

SN - 0344-5704

IS - 5

ER -