Abstract
Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly(dl-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method. A fast release of drug in PBS (pH 7.4) at 37 °C resulting in 100% release within 5 h was observed for both drugs. The rate of drug release was substantially reduced by treating the particles with gelatin or albumin after drug loading, resulting in a linear drug release in time. It was shown that the rate of drug release is related to the amount of protein associated with the nanoparticles. After gelatin treatment of drug-loaded nanoparticles, sustained release of dexamethasone for 17 days and of rapamycin for 50 days could be achieved.
Original language | Undefined |
---|---|
Pages (from-to) | 317-324 |
Journal | Journal of controlled release |
Volume | 114 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2007 |
Keywords
- Restenosis
- Rapamycin
- IR-71911
- Dexamethasone
- METIS-236841
- Biodegradable nanoparticles