Reliability and reproducibility of automated contour analysis in intravascular ultrasound images of femoropopliteal arteries

Aad van der Lugt, Aran Hartlooper, Jerden A. van Essen, Wenguang Li, Clemens von Birgelen, Johan H.C. Reiber, Elma J. Gussenhoven* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)


An automated contour analysis system was previously developed to increase reproducibility and facilitate quantitative analyses of intravascular ultrasound (IVUS) images. The aim of this study was to compare measurements by this automated system with those obtained by conventional manual tracing, and to determine the intra- and interobserver variability of the automated system. IVUS images obtained in the femoropopliteal artery (n = 12) were analyzed with both systems. Area measurements by the automated system agreed with with the results obtained by manual tracing, displaying low coefficients of variation (8.5 to 15.7%) and high correlation coefficients (r = 0.92 to 0.98). Intra- and interobserver comparison of lumen area, vessel area, plaque area and percentage area stenosis showed low coefficients of variation (6.0 to 15.3% and 5.7 to 14.0%, respectively) and high correlation coefficients (both: r = 0.93 to 0.99). These data indicate that the automated analysis system is a reliable tool for the quantitative assessment of vessel dimensions in IVUS images obtained during clinical examination of peripheral arteries.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalUltrasound in medicine and biology
Issue number1
Publication statusPublished - 1 Jan 1998
Externally publishedYes


  • Atherosclerosis
  • Contour detection
  • Intravascular ultrasound
  • Peripheral arteries

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