Removal of low density lipoprotein from blood plasma using cross-linked, sulfated polyvinylalcohol

N. Maaskant, A. Bantjes, H.J.M. Kempen

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Abstract

The properties of a new synthetic LDL binding material, consisting of fragments of loosely crosslinked hydrogel, based on sulfated polyvinylalcohol are described. When incubated with 20 times its volume of plasma, this material binds up to 95% of the LDL, even from plasma with severely elevated LDL cholesterol levels (up to 20 mM). In addition a cholesterol-rich subfraction of VLDL is bound but HDL is not bound. After about 10 min binder/plasma contact the LDL removal is complete and no other additives are required. LDL binding capacity is dependent on the average binder particle size, indicating a restricted penetration of LDL particles into the binder matrix.
Original languageEnglish
Pages (from-to)159-166
JournalAtherosclerosis
Volume62
Issue number2
DOIs
Publication statusPublished - 1986

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LDL Lipoproteins
Plasma Volume
Hydrogel
Hypercholesterolemia
Particle Size
LDL Cholesterol
Cholesterol
oxidized low density lipoprotein

Keywords

  • IR-69622

Cite this

Maaskant, N. ; Bantjes, A. ; Kempen, H.J.M. / Removal of low density lipoprotein from blood plasma using cross-linked, sulfated polyvinylalcohol. In: Atherosclerosis. 1986 ; Vol. 62, No. 2. pp. 159-166.
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Removal of low density lipoprotein from blood plasma using cross-linked, sulfated polyvinylalcohol. / Maaskant, N.; Bantjes, A.; Kempen, H.J.M.

In: Atherosclerosis, Vol. 62, No. 2, 1986, p. 159-166.

Research output: Contribution to journalArticleAcademic

TY - JOUR

T1 - Removal of low density lipoprotein from blood plasma using cross-linked, sulfated polyvinylalcohol

AU - Maaskant, N.

AU - Bantjes, A.

AU - Kempen, H.J.M.

PY - 1986

Y1 - 1986

N2 - The properties of a new synthetic LDL binding material, consisting of fragments of loosely crosslinked hydrogel, based on sulfated polyvinylalcohol are described. When incubated with 20 times its volume of plasma, this material binds up to 95% of the LDL, even from plasma with severely elevated LDL cholesterol levels (up to 20 mM). In addition a cholesterol-rich subfraction of VLDL is bound but HDL is not bound. After about 10 min binder/plasma contact the LDL removal is complete and no other additives are required. LDL binding capacity is dependent on the average binder particle size, indicating a restricted penetration of LDL particles into the binder matrix.

AB - The properties of a new synthetic LDL binding material, consisting of fragments of loosely crosslinked hydrogel, based on sulfated polyvinylalcohol are described. When incubated with 20 times its volume of plasma, this material binds up to 95% of the LDL, even from plasma with severely elevated LDL cholesterol levels (up to 20 mM). In addition a cholesterol-rich subfraction of VLDL is bound but HDL is not bound. After about 10 min binder/plasma contact the LDL removal is complete and no other additives are required. LDL binding capacity is dependent on the average binder particle size, indicating a restricted penetration of LDL particles into the binder matrix.

KW - IR-69622

U2 - 10.1016/0021-9150(86)90062-6

DO - 10.1016/0021-9150(86)90062-6

M3 - Article

VL - 62

SP - 159

EP - 166

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -