Repeatability of Bolus Kinetics Ultrasound Perfusion Imaging for the Quantification of Cerebral Blood Flow

Elisabeth J. Vinke, Jens Eyding, Chris L. de Korte, Cornelis H. Slump, Johannes G. van der Hoeven, Cornelia W.E. Hoedemaekers*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    2 Citations (Scopus)
    26 Downloads (Pure)


    Ultrasound perfusion imaging (UPI) can be used for the quantification of cerebral perfusion. In a neuro-intensive care setting, repeated measurements are required to evaluate changes in cerebral perfusion and monitor therapy. The aim of this study was to determine the repeatability of UPI in quantification of cerebral perfusion. UPI measurement of cerebral perfusion was performed three times in healthy patients. The coefficients of variation of the three bolus injections were calculated for both time- and volume-derived perfusion parameters in the macro- and microcirculation. The UPI time-dependent parameters had overall the lowest CVs in both the macro- and microcirculation. The volume-related parameters had poorer repeatability, especially in the microcirculation. Both intra-observer variability and inter-observer variability were low. Although UPI is a promising tool for the bedside measurement of cerebral perfusion, improvement of the technique is required before implementation in routine clinical practice.

    Original languageEnglish
    Pages (from-to)2758-2764
    Number of pages7
    JournalUltrasound in medicine and biology
    Issue number12
    Early online date28 Sept 2017
    Publication statusPublished - Dec 2017


    • Acute brain injury
    • Cerebral blood flow
    • Contrast-enhanced ultrasound
    • Intensive care
    • Monitoring
    • Ultrasound perfusion imaging
    • 2023 OA procedure


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