Reproducibility of volumetric intravascular ultrasound radiofrequency-based analysis of coronary plaque composition in vivo

Marc Hartmann, Eline S. Mattern, Jennifer Huisman, Gert K. van Houwelingen, Frits H.A.F. de Man, Martin G. Stoel, Peter W. Danse, Hans W. Louwerenburg, Clemens von Birgelen

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Abstract

Intravascular ultrasound radiofrequency (RF-IVUS) data permit the analysis of coronary plaque composition in vivo and is used as an endpoint of ongoing pharmacological intervention trials. We assessed the reproducibility of volumetric RF-IVUS analyses in mild-to-moderately diseased atherosclerotic human coronary arteries in vivo. A total of 9,212 IVUS analyses on cross-sectional IVUS frames was performed to evaluate the reproducibility of volumetric RF-IVUS measurements in 33 coronary segments with a length of 27 ± 7 mm. For vessel, lumen, and plaque + media volume the relative measurement differences (P = NS for all) were (A = intraobserver comparison, same pullback) −0.40 ± 1.0%; −0.48 ± 1.4%; −0.35 ± 1.6%, (B = intraobserver comparison, repeated pullback) −0.42 ± 1.2%; −0.52 ± 1.8%; −0.43 ± 4.5% (C = interobserver comparison, same pullback) 0.71 ± 1.8%; 0.71 ± 2.2%, and 0.89 ± 5.0%, respectively. For fibrous, fibro-lipidic, calcium, and necrotic-core volumes the relative measurement differences (P = NS for all) were (A) 0.45 ± 2.1%; −1.12 ± 4.9%; −0.84 ± 2.1%; −0.22 ± 1.8%, (B) 1.40 ± 4.1%; 1.26 ± 6.7%; 2.66 ± 7.4%; 0.85 ± 4.4%, and (C) −1.60 ± 4.9%; 3.85 ± 8.2%; 1.66 ± 7.5%, and −1.58 ± 4.7%, respectively. Of note, necrotic-core volume showed on average the lowest measurement variability. Thus, in mild-to-moderate atherosclerotic coronary artery disease the reproducibility of volumetric compositional RF-IVUS measurements from the same pullback is relatively high, but lower than the reproducibility of geometrical IVUS measurements. Measurements from repeated pullbacks and by different observers show acceptable reproducibilities; the volumetric measurement of the necrotic-core shows on average the highest reproducibility of the compositional RF-IVUS measurements
Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalInternational journal of cardiovascular imaging
Volume25
Issue number1
DOIs
Publication statusPublished - 2009

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Coronary Artery Disease
Coronary Vessels
Cross-Sectional Studies
Pharmacology
Calcium

Keywords

  • Coronary disease
  • Ultrasonics
  • Radiofrequency
  • Virtual histology

Cite this

Hartmann, Marc ; Mattern, Eline S. ; Huisman, Jennifer ; van Houwelingen, Gert K. ; de Man, Frits H.A.F. ; Stoel, Martin G. ; Danse, Peter W. ; Louwerenburg, Hans W. ; von Birgelen, Clemens. / Reproducibility of volumetric intravascular ultrasound radiofrequency-based analysis of coronary plaque composition in vivo. In: International journal of cardiovascular imaging. 2009 ; Vol. 25, No. 1. pp. 13-23.
@article{cc2bf50669084ca68c10b733422a83b5,
title = "Reproducibility of volumetric intravascular ultrasound radiofrequency-based analysis of coronary plaque composition in vivo",
abstract = "Intravascular ultrasound radiofrequency (RF-IVUS) data permit the analysis of coronary plaque composition in vivo and is used as an endpoint of ongoing pharmacological intervention trials. We assessed the reproducibility of volumetric RF-IVUS analyses in mild-to-moderately diseased atherosclerotic human coronary arteries in vivo. A total of 9,212 IVUS analyses on cross-sectional IVUS frames was performed to evaluate the reproducibility of volumetric RF-IVUS measurements in 33 coronary segments with a length of 27 ± 7 mm. For vessel, lumen, and plaque + media volume the relative measurement differences (P = NS for all) were (A = intraobserver comparison, same pullback) −0.40 ± 1.0{\%}; −0.48 ± 1.4{\%}; −0.35 ± 1.6{\%}, (B = intraobserver comparison, repeated pullback) −0.42 ± 1.2{\%}; −0.52 ± 1.8{\%}; −0.43 ± 4.5{\%} (C = interobserver comparison, same pullback) 0.71 ± 1.8{\%}; 0.71 ± 2.2{\%}, and 0.89 ± 5.0{\%}, respectively. For fibrous, fibro-lipidic, calcium, and necrotic-core volumes the relative measurement differences (P = NS for all) were (A) 0.45 ± 2.1{\%}; −1.12 ± 4.9{\%}; −0.84 ± 2.1{\%}; −0.22 ± 1.8{\%}, (B) 1.40 ± 4.1{\%}; 1.26 ± 6.7{\%}; 2.66 ± 7.4{\%}; 0.85 ± 4.4{\%}, and (C) −1.60 ± 4.9{\%}; 3.85 ± 8.2{\%}; 1.66 ± 7.5{\%}, and −1.58 ± 4.7{\%}, respectively. Of note, necrotic-core volume showed on average the lowest measurement variability. Thus, in mild-to-moderate atherosclerotic coronary artery disease the reproducibility of volumetric compositional RF-IVUS measurements from the same pullback is relatively high, but lower than the reproducibility of geometrical IVUS measurements. Measurements from repeated pullbacks and by different observers show acceptable reproducibilities; the volumetric measurement of the necrotic-core shows on average the highest reproducibility of the compositional RF-IVUS measurements",
keywords = "Coronary disease, Ultrasonics, Radiofrequency, Virtual histology",
author = "Marc Hartmann and Mattern, {Eline S.} and Jennifer Huisman and {van Houwelingen}, {Gert K.} and {de Man}, {Frits H.A.F.} and Stoel, {Martin G.} and Danse, {Peter W.} and Louwerenburg, {Hans W.} and {von Birgelen}, Clemens",
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Reproducibility of volumetric intravascular ultrasound radiofrequency-based analysis of coronary plaque composition in vivo. / Hartmann, Marc; Mattern, Eline S.; Huisman, Jennifer; van Houwelingen, Gert K.; de Man, Frits H.A.F.; Stoel, Martin G.; Danse, Peter W.; Louwerenburg, Hans W.; von Birgelen, Clemens.

In: International journal of cardiovascular imaging, Vol. 25, No. 1, 2009, p. 13-23.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Reproducibility of volumetric intravascular ultrasound radiofrequency-based analysis of coronary plaque composition in vivo

AU - Hartmann, Marc

AU - Mattern, Eline S.

AU - Huisman, Jennifer

AU - van Houwelingen, Gert K.

AU - de Man, Frits H.A.F.

AU - Stoel, Martin G.

AU - Danse, Peter W.

AU - Louwerenburg, Hans W.

AU - von Birgelen, Clemens

PY - 2009

Y1 - 2009

N2 - Intravascular ultrasound radiofrequency (RF-IVUS) data permit the analysis of coronary plaque composition in vivo and is used as an endpoint of ongoing pharmacological intervention trials. We assessed the reproducibility of volumetric RF-IVUS analyses in mild-to-moderately diseased atherosclerotic human coronary arteries in vivo. A total of 9,212 IVUS analyses on cross-sectional IVUS frames was performed to evaluate the reproducibility of volumetric RF-IVUS measurements in 33 coronary segments with a length of 27 ± 7 mm. For vessel, lumen, and plaque + media volume the relative measurement differences (P = NS for all) were (A = intraobserver comparison, same pullback) −0.40 ± 1.0%; −0.48 ± 1.4%; −0.35 ± 1.6%, (B = intraobserver comparison, repeated pullback) −0.42 ± 1.2%; −0.52 ± 1.8%; −0.43 ± 4.5% (C = interobserver comparison, same pullback) 0.71 ± 1.8%; 0.71 ± 2.2%, and 0.89 ± 5.0%, respectively. For fibrous, fibro-lipidic, calcium, and necrotic-core volumes the relative measurement differences (P = NS for all) were (A) 0.45 ± 2.1%; −1.12 ± 4.9%; −0.84 ± 2.1%; −0.22 ± 1.8%, (B) 1.40 ± 4.1%; 1.26 ± 6.7%; 2.66 ± 7.4%; 0.85 ± 4.4%, and (C) −1.60 ± 4.9%; 3.85 ± 8.2%; 1.66 ± 7.5%, and −1.58 ± 4.7%, respectively. Of note, necrotic-core volume showed on average the lowest measurement variability. Thus, in mild-to-moderate atherosclerotic coronary artery disease the reproducibility of volumetric compositional RF-IVUS measurements from the same pullback is relatively high, but lower than the reproducibility of geometrical IVUS measurements. Measurements from repeated pullbacks and by different observers show acceptable reproducibilities; the volumetric measurement of the necrotic-core shows on average the highest reproducibility of the compositional RF-IVUS measurements

AB - Intravascular ultrasound radiofrequency (RF-IVUS) data permit the analysis of coronary plaque composition in vivo and is used as an endpoint of ongoing pharmacological intervention trials. We assessed the reproducibility of volumetric RF-IVUS analyses in mild-to-moderately diseased atherosclerotic human coronary arteries in vivo. A total of 9,212 IVUS analyses on cross-sectional IVUS frames was performed to evaluate the reproducibility of volumetric RF-IVUS measurements in 33 coronary segments with a length of 27 ± 7 mm. For vessel, lumen, and plaque + media volume the relative measurement differences (P = NS for all) were (A = intraobserver comparison, same pullback) −0.40 ± 1.0%; −0.48 ± 1.4%; −0.35 ± 1.6%, (B = intraobserver comparison, repeated pullback) −0.42 ± 1.2%; −0.52 ± 1.8%; −0.43 ± 4.5% (C = interobserver comparison, same pullback) 0.71 ± 1.8%; 0.71 ± 2.2%, and 0.89 ± 5.0%, respectively. For fibrous, fibro-lipidic, calcium, and necrotic-core volumes the relative measurement differences (P = NS for all) were (A) 0.45 ± 2.1%; −1.12 ± 4.9%; −0.84 ± 2.1%; −0.22 ± 1.8%, (B) 1.40 ± 4.1%; 1.26 ± 6.7%; 2.66 ± 7.4%; 0.85 ± 4.4%, and (C) −1.60 ± 4.9%; 3.85 ± 8.2%; 1.66 ± 7.5%, and −1.58 ± 4.7%, respectively. Of note, necrotic-core volume showed on average the lowest measurement variability. Thus, in mild-to-moderate atherosclerotic coronary artery disease the reproducibility of volumetric compositional RF-IVUS measurements from the same pullback is relatively high, but lower than the reproducibility of geometrical IVUS measurements. Measurements from repeated pullbacks and by different observers show acceptable reproducibilities; the volumetric measurement of the necrotic-core shows on average the highest reproducibility of the compositional RF-IVUS measurements

KW - Coronary disease

KW - Ultrasonics

KW - Radiofrequency

KW - Virtual histology

U2 - 10.1007/s10554-008-9338-9

DO - 10.1007/s10554-008-9338-9

M3 - Article

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SP - 13

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JO - International journal of cardiovascular imaging

JF - International journal of cardiovascular imaging

SN - 1569-5794

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ER -