Responsive crosslinked polymer nanogels for imaging and therapeutics delivery

Antonie E. Ekkelenkamp, M. Rachèl Elzes, Johan F.J. Engbersen, Jos M.J. Paulusse* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

88 Citations (Scopus)
72 Downloads (Pure)


Water-soluble, nano-sized crosslinked polymer networks, or nanogels, are delivery vehicles, which have highly interesting properties for therapeutic delivery and imaging. Nanogels may also possess responsive properties, depending on the employed polymers, allowing controlled release of therapeutics or image contrast generation upon exposure to physical or (bio)chemical cues. In this review, polymer nanogels are explored for application in imaging as well as for controlled drug and gene delivery. Moreover, nanogels are explored as responsive biomaterials and future applications are highlighted.

Original languageEnglish
Pages (from-to)210-235
Number of pages26
JournalJournal of materials chemistry. B: materials for biology and medicine
Issue number2
Publication statusPublished - 14 Jan 2018


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