TY - JOUR
T1 - Responsive crosslinked polymer nanogels for imaging and therapeutics delivery
AU - Ekkelenkamp, Antonie E.
AU - Elzes, M. Rachèl
AU - Engbersen, Johan F.J.
AU - Paulusse, Jos M.J.
PY - 2018/1/14
Y1 - 2018/1/14
N2 - Water-soluble, nano-sized crosslinked polymer networks, or nanogels, are delivery vehicles, which have highly interesting properties for therapeutic delivery and imaging. Nanogels may also possess responsive properties, depending on the employed polymers, allowing controlled release of therapeutics or image contrast generation upon exposure to physical or (bio)chemical cues. In this review, polymer nanogels are explored for application in imaging as well as for controlled drug and gene delivery. Moreover, nanogels are explored as responsive biomaterials and future applications are highlighted.
AB - Water-soluble, nano-sized crosslinked polymer networks, or nanogels, are delivery vehicles, which have highly interesting properties for therapeutic delivery and imaging. Nanogels may also possess responsive properties, depending on the employed polymers, allowing controlled release of therapeutics or image contrast generation upon exposure to physical or (bio)chemical cues. In this review, polymer nanogels are explored for application in imaging as well as for controlled drug and gene delivery. Moreover, nanogels are explored as responsive biomaterials and future applications are highlighted.
KW - 22/4 OA procedure
UR - http://www.scopus.com/inward/record.url?scp=85040188081&partnerID=8YFLogxK
U2 - 10.1039/c7tb02239e
DO - 10.1039/c7tb02239e
M3 - Review article
AN - SCOPUS:85040188081
VL - 6
SP - 210
EP - 235
JO - Journal of materials chemistry. B: materials for biology and medicine
JF - Journal of materials chemistry. B: materials for biology and medicine
SN - 2050-750X
IS - 2
ER -