Review: Bioelectrical mechanisms in spinal cord stimulation

J. Holsheimer, Jan R. Buitenweg

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    Objectives The aim of this review is to make specialists in a variety of disciplines familiar with basic aspects of spinal cord stimulation and the role of mathematical modeling in understanding its mechanisms of action and the solution of basic problems. Methods The paper is divided into five sections. The content of each section also covers aspects of various disciplines. Most aspects are presented in an unusual way, likely resulting in new viewpoints and further developments in the growing field of neuromodulation. Results A special, integrating role is the mathematical modeling of spinal cord stimulation and the simulation studies of various aspects, such as the stimulation in axial low-back pain. Conclusions In particular the conclusions from several computer simulation studies are relevant and of interest to specialists in many disciplines. © 2015 International Neuromodulation Society.
    Original languageUndefined
    Pages (from-to)161-170
    Number of pages10
    Issue number3
    Publication statusPublished - 2015


    • METIS-315592
    • IR-99375
    • Low Back Pain
    • Electrode paddle
    • Spinal cord stimulation
    • Stimulation
    • EWI-26813
    • review article
    • BSS-Central mechanisms underlying chronic pain
    • Electrode paddlelow back painreview articlespinal cord stimulationstimulationcell selectioncell sizecerebrospinal fluidclinical trial (topic)computer simulationcuneate fascicledermatomedual lead stimulationequipment designevoked somatosensory responsefinite element modelgracile fasciclehumanlaminectomy leadmathematical analysismathematical modelnerve fiber sortingnerve stimulatornerve tractneuromodulationneurophysiological recruitmentneurophysiologyparesthesiapercutaneous leadrandomized controlled trial (topic)Reviewsingle lead stimulationspinal cord dorsal hornspinal cord stimulatoranimalBack Painelectrode implantphysiologyproceduresspinal cordAnimalsElectrodes
    • ImplantedHumans

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