Review of laser speckle contrast techniques for visualizing tissue perfusion

Matthijs Draijer, Erwin Hondebrink, Ton van Leeuwen, Wiendelt Steenbergen

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When a diffuse object is illuminated with coherent laser light, the backscattered light will form an interference pattern on the detector. This pattern of bright and dark areas is called a speckle pattern. When there is movement in the object, the speckle pattern will change over time. Laser speckle contrast techniques use this change in speckle pattern to visualize tissue perfusion. We present and review the contribution of laser speckle contrast techniques to the field of perfusion visualization and discuss the development of the techniques.
Original languageUndefined
Pages (from-to)639-651
Number of pages13
JournalLasers in medical science
Issue number4
Publication statusPublished - 2009


  • IR-76388
  • METIS-258858

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