Risk management of risk management: Combining proton pump inhibitors with low-dose aspirin

Harald Vonkeman* (Corresponding Author), Inger Meek, Mart van de Laar

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

    2 Citations (Scopus)
    38 Downloads (Pure)

    Abstract

    Low-dose aspirin is widely used in the primary and secondary prevention of cardiovascular events, but is associated with a range of upper gastrointestinal side effects. In this review, we summarize the rationale for low-dose aspirin therapy, quantify the risk for upper gastrointestinal side effects, identify the risk factors involved, and provide an overview of preventive strategies, thereby focusing on the rationale and clinical utility of combining proton-pump inhibitors with low-dose aspirin.

    Original languageEnglish
    Pages (from-to)191-204
    Number of pages14
    JournalDrug, Healthcare and Patient Safety
    Volume2
    Issue number1
    DOIs
    Publication statusPublished - 6 Oct 2010

    Keywords

    • Clopidogrel
    • Gastrointestinal ulcers
    • H-receptor antagonists
    • Helicobacter pylori
    • Low-dose aspirin
    • Proton-pump inhibitors

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