Role for glycocalyx perturbation in atherosclerosis development and associated microvascular dysfunction

Judith Brands; Jurgen W.G.E. Van Teeffelen; Bernard M. Van den Berg; Hans Vink

doi:10.2217/17460875.2.5.527

Role for glycocalyx perturbation in atherosclerosis development and associated microvascular dysfunction

Judith Brands, Jurgen W.G.E. Van Teeffelen, Bernard M. Van den Berg, Hans Vink^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

8 Citations (Scopus)

4 Downloads (Pure)

Abstract

The importance of the endothelial glycocalyx for vascular homeostasis is becoming more and more evident. This review addresses the potential relation between a damaged glycocalyx and the process of atherosclerosis, including the associated impairment in blood-flow regulation. We envision restoration of glycocalyx perturbation in the future as a potential therapy for early treatment of cardiovascular disease.

Original language	English
Pages (from-to)	527-534
Number of pages	8
Journal	Future Lipidology
Volume	2
Issue number	5
DOIs	https://doi.org/10.2217/17460875.2.5.527
Publication status	Published - 1 Oct 2007
Externally published	Yes

Keywords

Atherosclerosis
Blood flow regulation
Capillaries
Endothelial dysfunction
Flow-dependent dilation
Glycocalyx

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