Role for glycocalyx perturbation in atherosclerosis development and associated microvascular dysfunction

Judith Brands, Jurgen W.G.E. Van Teeffelen, Bernard M. Van den Berg, Hans Vink*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

8 Citations (Scopus)
2 Downloads (Pure)

Abstract

The importance of the endothelial glycocalyx for vascular homeostasis is becoming more and more evident. This review addresses the potential relation between a damaged glycocalyx and the process of atherosclerosis, including the associated impairment in blood-flow regulation. We envision restoration of glycocalyx perturbation in the future as a potential therapy for early treatment of cardiovascular disease.

Original languageEnglish
Pages (from-to)527-534
Number of pages8
JournalFuture Lipidology
Volume2
Issue number5
DOIs
Publication statusPublished - 1 Oct 2007
Externally publishedYes

Keywords

  • Atherosclerosis
  • Blood flow regulation
  • Capillaries
  • Endothelial dysfunction
  • Flow-dependent dilation
  • Glycocalyx

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