Routine and interval detection of locoregional breast cancer recurrences and risk of subsequent distant metastasis

Anouk Eijkelboom*, Linda de Munck, Maaike de Vries, Anne Brecht Francken, Mathijs P. Hendriks, Luc J.A. Strobbe, Annemieke Witteveen, Marissa C. van Maaren, Sabine Siesling

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
18 Downloads (Pure)


Purpose: Follow-up for breast cancer survivors consists of after care and surveillance. The benefits of routine surveillance visits remain debatable. In this study we compared the severity of locoregional recurrences (LRRs) and the subsequent risk of a distant metastasis (DM) between LRRs detected at routine and interval visits.

Methods: Women diagnosed with early breast cancer between 2003 and 2008 in one of the 15 participating hospitals, and who developed a LRR as first event after primary treatment, were selected from the Netherlands Cancer Registry (Cohort A). Chi-squared tests were used to compare the severity of routine- and interval-detected local recurrences (LRs) and regional recurrences (RRs), using tumor size, tumor grade, and number of positive lymph nodes. Data on the development of a subsequent DM after a LRR were available for a subset of patients (Cohort B). Cohort B was used to estimate the association between way of LRR-detection and risk of a DM.

Results: Cohort A consisted of 109 routine- and 113 interval-LRR patients. The severity of routine-detected LRs or RRs and interval-detected LRs or RRs did not significantly differ. Cohort B consisted of 66 routine- and 61 interval-LRR patients. Sixteen routine- (24%) and 17 (28%) interval-LRR patients developed a DM. After adjustment, way of LRR-detection was not significantly associated with the risk of a DM (hazard ratio: 1.22; 95% confidence interval: 0.49–3.06).

Conclusion: The current study showed that routine visits did not lead to less severe LRRs and did not decrease the risk of a subsequent DM.
Original languageEnglish
Pages (from-to)123–135
Number of pages13
JournalBreast cancer research and treatment
Issue number1
Early online date31 Oct 2022
Publication statusPublished - Jan 2023


  • UT-Hybrid-D


Dive into the research topics of 'Routine and interval detection of locoregional breast cancer recurrences and risk of subsequent distant metastasis'. Together they form a unique fingerprint.

Cite this