Ruthenium oxide nanorods as potentiometric ph sensor for organs-on-chip purposes

Esther Tanumihardja; Wouter Olthuis; Albert van den Berg

doi:10.3390/s18092901

Ruthenium oxide nanorods as potentiometric ph sensor for organs-on-chip purposes

Esther Tanumihardja^* (Corresponding Author), Wouter Olthuis, Albert van den Berg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A ruthenium oxide (RuOx) sensor for potentiometric pH sensing is currently being developed for organs-on-chip purposes. The sensor was fabricated from a Ru(OH)₃ precursor, resulting in RuOx nanorods after heating. An open-circuit potential of the RuOx electrode showed a near-Nernstian response of −58.05 mV/pH, with good selectivity against potentially interfering ions (lithium, sulfate, chloride, and calcium ions). The preconditioned electrode (stored in liquid) had a long-term drift of −0.8 mV/h, and its response rate was less than 2 s. Sensitivity to oxygen was observed at an order of magnitude lower than other reported metal-oxide pH sensors. Together with miniaturizability, the RuOx pH sensor proves to be a suitable pH sensor for organs-on-chip studies.

Original language	English
Article number	2901
Journal	Sensors (Switzerland)
Volume	18
Issue number	9
DOIs	https://doi.org/10.3390/s18092901
Publication status	Published - 1 Sept 2018

Keywords

Organs-on-chip
pH sensor
Potentiometric sensor
Ruthenium oxide
Lab-on-chip

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10.3390/s18092901Licence: CC BY

Tanumihardja2018rutheniumFinal published version, 2.78 MBLicence: CC BY

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abstract = "A ruthenium oxide (RuOx) sensor for potentiometric pH sensing is currently being developed for organs-on-chip purposes. The sensor was fabricated from a Ru(OH)3 precursor, resulting in RuOx nanorods after heating. An open-circuit potential of the RuOx electrode showed a near-Nernstian response of −58.05 mV/pH, with good selectivity against potentially interfering ions (lithium, sulfate, chloride, and calcium ions). The preconditioned electrode (stored in liquid) had a long-term drift of −0.8 mV/h, and its response rate was less than 2 s. Sensitivity to oxygen was observed at an order of magnitude lower than other reported metal-oxide pH sensors. Together with miniaturizability, the RuOx pH sensor proves to be a suitable pH sensor for organs-on-chip studies.",

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Ruthenium oxide nanorods as potentiometric ph sensor for organs-on-chip purposes

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