Ruthenium Oxide pH Sensing for Organs-On-Chip Studies

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    A ruthenium oxide (RuOx) electrode is being developed as potentiometric pH sensor for organs-on-chip applications. Open-circuit potential (OCP) of the RuOx electrode showed a response of −58.05 mV/pH, with no cross-sensitivity to potentially interfering/complexing ions (tested were lithium, sulfate, chloride, and calcium ions). Similar response was observed in complex biological medium. The electrode stored in liquid had a long-term drift of −0.8 mV/hour (corresponding to ΔpH of 0.013/hour) and response time in complex biological medium was 3.7 s. Minimum cross-sensitivity to oxygen was observed as the OCP shifted ~3 mV going from deoxygenated to oxygenated solution. This response is one magnitude lower than previously reported for metal- oxide pH sensors. Overall, the RuOx pH sensor has proven to be a suitable pH sensor for organs- on-chip applications.
    Original languageEnglish
    Title of host publicationProceedings of Eurosensors 2018
    Place of PublicationBasel, Switzerland
    PublisherMultidisciplinary Digital Publishing Institute (MDPI)
    Number of pages4
    Publication statusPublished - 5 Dec 2018
    Event32nd European Conference on Solid-State Transducers, Eurosensors XXXII 2018 - Graz, Austria
    Duration: 9 Sep 201812 Sep 2018
    Conference number: 32

    Publication series

    NameProceedings (MDPI)
    PublisherMultidisciplinary Digital Publishing Institute
    ISSN (Print)2504-3900


    Conference32nd European Conference on Solid-State Transducers, Eurosensors XXXII 2018
    Abbreviated titleEurosensors
    Internet address


    • potentiometric sensor
    • pH sensor
    • organs-on-chip
    • ruthenium oxide


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