Ruthenium Oxide pH Sensing for Organs-On-Chip Studies

Esther  Tanumihardja; Wouter  Olthuis; Albert  van den Berg

doi:10.3390/proceedings2130709

Ruthenium Oxide pH Sensing for Organs-On-Chip Studies

Esther Tanumihardja, Wouter Olthuis, Albert van den Berg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

A ruthenium oxide (RuOx) electrode is being developed as potentiometric pH sensor for organs-on-chip applications. Open-circuit potential (OCP) of the RuOx electrode showed a response of −58.05 mV/pH, with no cross-sensitivity to potentially interfering/complexing ions (tested were lithium, sulfate, chloride, and calcium ions). Similar response was observed in complex biological medium. The electrode stored in liquid had a long-term drift of −0.8 mV/hour (corresponding to ΔpH of 0.013/hour) and response time in complex biological medium was 3.7 s. Minimum cross-sensitivity to oxygen was observed as the OCP shifted ~3 mV going from deoxygenated to oxygenated solution. This response is one magnitude lower than previously reported for metal- oxide pH sensors. Overall, the RuOx pH sensor has proven to be a suitable pH sensor for organs- on-chip applications.

Original language	English
Title of host publication	Proceedings of Eurosensors 2018
Place of Publication	Basel, Switzerland
Publisher	MDPI
Pages	1-4
Number of pages	4
Volume	2
Edition	13
DOIs	https://doi.org/10.3390/proceedings2130709
Publication status	Published - 5 Dec 2018
Event	32nd European Conference on Solid-State Transducers, Eurosensors XXXII 2018 - Graz, Austria Duration: 9 Sep 2018 → 12 Sep 2018 Conference number: 32 http://www.eurosensors2018.eu

Publication series

Name	Proceedings (MDPI)
Publisher	Multidisciplinary Digital Publishing Institute
ISSN (Print)	2504-3900

Conference

Conference	32nd European Conference on Solid-State Transducers, Eurosensors XXXII 2018
Abbreviated title	Eurosensors
Country/Territory	Austria
City	Graz
Period	9/09/18 → 12/09/18
Internet address	http://www.eurosensors2018.eu

Keywords

potentiometric sensor
pH sensor
organs-on-chip
ruthenium oxide

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proceedings-02-00709Final published version, 685 KBLicence: CC BY

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title = "Ruthenium Oxide pH Sensing for Organs-On-Chip Studies",

abstract = "A ruthenium oxide (RuOx) electrode is being developed as potentiometric pH sensor for organs-on-chip applications. Open-circuit potential (OCP) of the RuOx electrode showed a response of −58.05 mV/pH, with no cross-sensitivity to potentially interfering/complexing ions (tested were lithium, sulfate, chloride, and calcium ions). Similar response was observed in complex biological medium. The electrode stored in liquid had a long-term drift of −0.8 mV/hour (corresponding to ΔpH of 0.013/hour) and response time in complex biological medium was 3.7 s. Minimum cross-sensitivity to oxygen was observed as the OCP shifted ~3 mV going from deoxygenated to oxygenated solution. This response is one magnitude lower than previously reported for metal- oxide pH sensors. Overall, the RuOx pH sensor has proven to be a suitable pH sensor for organs- on-chip applications.",

keywords = "potentiometric sensor, pH sensor, organs-on-chip, ruthenium oxide",

author = "Esther Tanumihardja and Wouter Olthuis and {van den Berg}, Albert",

year = "2018",

month = dec,

day = "5",

doi = "10.3390/proceedings2130709",

language = "English",

volume = "2",

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pages = "1--4",

booktitle = "Proceedings of Eurosensors 2018",

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T1 - Ruthenium Oxide pH Sensing for Organs-On-Chip Studies

AU - Tanumihardja, Esther

AU - Olthuis, Wouter

AU - van den Berg, Albert

N1 - Conference code: 32

PY - 2018/12/5

Y1 - 2018/12/5

N2 - A ruthenium oxide (RuOx) electrode is being developed as potentiometric pH sensor for organs-on-chip applications. Open-circuit potential (OCP) of the RuOx electrode showed a response of −58.05 mV/pH, with no cross-sensitivity to potentially interfering/complexing ions (tested were lithium, sulfate, chloride, and calcium ions). Similar response was observed in complex biological medium. The electrode stored in liquid had a long-term drift of −0.8 mV/hour (corresponding to ΔpH of 0.013/hour) and response time in complex biological medium was 3.7 s. Minimum cross-sensitivity to oxygen was observed as the OCP shifted ~3 mV going from deoxygenated to oxygenated solution. This response is one magnitude lower than previously reported for metal- oxide pH sensors. Overall, the RuOx pH sensor has proven to be a suitable pH sensor for organs- on-chip applications.

AB - A ruthenium oxide (RuOx) electrode is being developed as potentiometric pH sensor for organs-on-chip applications. Open-circuit potential (OCP) of the RuOx electrode showed a response of −58.05 mV/pH, with no cross-sensitivity to potentially interfering/complexing ions (tested were lithium, sulfate, chloride, and calcium ions). Similar response was observed in complex biological medium. The electrode stored in liquid had a long-term drift of −0.8 mV/hour (corresponding to ΔpH of 0.013/hour) and response time in complex biological medium was 3.7 s. Minimum cross-sensitivity to oxygen was observed as the OCP shifted ~3 mV going from deoxygenated to oxygenated solution. This response is one magnitude lower than previously reported for metal- oxide pH sensors. Overall, the RuOx pH sensor has proven to be a suitable pH sensor for organs- on-chip applications.

KW - potentiometric sensor

KW - pH sensor

KW - organs-on-chip

KW - ruthenium oxide

U2 - 10.3390/proceedings2130709

DO - 10.3390/proceedings2130709

M3 - Conference contribution

VL - 2

T3 - Proceedings (MDPI)

SP - 1

EP - 4

BT - Proceedings of Eurosensors 2018

PB - MDPI

CY - Basel, Switzerland

T2 - 32nd European Conference on Solid-State Transducers, Eurosensors XXXII 2018

Y2 - 9 September 2018 through 12 September 2018

ER -

Ruthenium Oxide pH Sensing for Organs-On-Chip Studies

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