Scalable enantioseparation of amino acid derivatives using continuous liquid-liquid extraction in a cascade of centrifugal contactor separators

Boelo Schuur, Andrew J. Hallett, Jozef G.M. Winkelman, Johannes G. De Vries, Hero J. Heeres

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)

Abstract

Using a cascade of six centrifugal contactor separators in a countercurrent liquid-liquid extraction mode allowed the separation of one of the enantiomers of 3,5-dinitrobenzoyl-leucine in 55% yield and 98% ee using a catalytic amount of a chiral host compound based on a cinchona alkaloid. This method allows the preparation of kilograms of enantiopure material in table-top-sized equipment that can be operated in a fume cupboard. The methodology can be easily scaled up to ton amounts as large- volume centrifugal contactor separators are commercially available as well.

Original languageEnglish
Pages (from-to)911-914
Number of pages4
JournalOrganic Process Research and Development
Volume13
Issue number5
DOIs
Publication statusPublished - 18 Sep 2009
Externally publishedYes

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