Selective 226RA2+ionophores provided by self-assembly of guanosine and isoguanosine deratives

F.W.B. van Leeuwen, Willem Verboom, Xiaodong Shi, J.T. Davis, Jeffery T. Davis, David Reinhoudt

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Abstract

The self-assembled guanosine (G 1)-based hexadecamers and isoguanosine (isoG 2)-based decamers are excellent 226Ra2+ selective ionophores even in the presence of excess alkali (Na+, K+, Rb+, and Cs+) and alkaline earth (Mg2+, Ca2+, Sr2+, and Ba2+) cations over the pH range 3-11. G 1 requires additional picrate anions to provide a neutral assembly, whereas the isoG 2 assembly extracts 226Ra2+ cations without any such additives. Both G 1-picrate and isoG 2 assemblies show 226Ra2+ extraction even at a 0.35 × 106 fold excess of Na+, K+, Rb+, Cs+, Mg2+, or Ca2+ (10-2 M) to 226Ra2+ (2.9 × 10-8 M) and at a 100-fold salt to ionophore excess. In the case of the G 1-picrate assembly, more competition was observed from Sr2+ and Ba2+, as extraction of 226Ra2+ ceased at an M2+/226Ra2+ ratio of 106 and 104, respectively. With the isoG 2 assembly, 226Ra2+ extraction also occurred at a Sr2+/226Ra2+ ratio of 106 but ceased at a 106 excess of Ba2+. The results clearly demonstrate the power of molecular self-assembly for the construction of highly selective ionophores.
Original languageUndefined
Pages (from-to)16575-16581
Number of pages7
JournalJournal of the American Chemical Society
Volume126
Issue number50
DOIs
Publication statusPublished - 2004

Keywords

  • METIS-222226
  • IR-49601

Cite this

van Leeuwen, F.W.B. ; Verboom, Willem ; Shi, Xiaodong ; Davis, J.T. ; Davis, Jeffery T. ; Reinhoudt, David. / Selective 226RA2+ionophores provided by self-assembly of guanosine and isoguanosine deratives. In: Journal of the American Chemical Society. 2004 ; Vol. 126, No. 50. pp. 16575-16581.
@article{9165635d57bd495694256956c811d6e6,
title = "Selective 226RA2+ionophores provided by self-assembly of guanosine and isoguanosine deratives",
abstract = "The self-assembled guanosine (G 1)-based hexadecamers and isoguanosine (isoG 2)-based decamers are excellent 226Ra2+ selective ionophores even in the presence of excess alkali (Na+, K+, Rb+, and Cs+) and alkaline earth (Mg2+, Ca2+, Sr2+, and Ba2+) cations over the pH range 3-11. G 1 requires additional picrate anions to provide a neutral assembly, whereas the isoG 2 assembly extracts 226Ra2+ cations without any such additives. Both G 1-picrate and isoG 2 assemblies show 226Ra2+ extraction even at a 0.35 × 106 fold excess of Na+, K+, Rb+, Cs+, Mg2+, or Ca2+ (10-2 M) to 226Ra2+ (2.9 × 10-8 M) and at a 100-fold salt to ionophore excess. In the case of the G 1-picrate assembly, more competition was observed from Sr2+ and Ba2+, as extraction of 226Ra2+ ceased at an M2+/226Ra2+ ratio of 106 and 104, respectively. With the isoG 2 assembly, 226Ra2+ extraction also occurred at a Sr2+/226Ra2+ ratio of 106 but ceased at a 106 excess of Ba2+. The results clearly demonstrate the power of molecular self-assembly for the construction of highly selective ionophores.",
keywords = "METIS-222226, IR-49601",
author = "{van Leeuwen}, F.W.B. and Willem Verboom and Xiaodong Shi and J.T. Davis and Davis, {Jeffery T.} and David Reinhoudt",
year = "2004",
doi = "10.1021/ja0455650 S0002-7863(04)05565-9",
language = "Undefined",
volume = "126",
pages = "16575--16581",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "50",

}

Selective 226RA2+ionophores provided by self-assembly of guanosine and isoguanosine deratives. / van Leeuwen, F.W.B.; Verboom, Willem; Shi, Xiaodong; Davis, J.T.; Davis, Jeffery T.; Reinhoudt, David.

In: Journal of the American Chemical Society, Vol. 126, No. 50, 2004, p. 16575-16581.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Selective 226RA2+ionophores provided by self-assembly of guanosine and isoguanosine deratives

AU - van Leeuwen, F.W.B.

AU - Verboom, Willem

AU - Shi, Xiaodong

AU - Davis, J.T.

AU - Davis, Jeffery T.

AU - Reinhoudt, David

PY - 2004

Y1 - 2004

N2 - The self-assembled guanosine (G 1)-based hexadecamers and isoguanosine (isoG 2)-based decamers are excellent 226Ra2+ selective ionophores even in the presence of excess alkali (Na+, K+, Rb+, and Cs+) and alkaline earth (Mg2+, Ca2+, Sr2+, and Ba2+) cations over the pH range 3-11. G 1 requires additional picrate anions to provide a neutral assembly, whereas the isoG 2 assembly extracts 226Ra2+ cations without any such additives. Both G 1-picrate and isoG 2 assemblies show 226Ra2+ extraction even at a 0.35 × 106 fold excess of Na+, K+, Rb+, Cs+, Mg2+, or Ca2+ (10-2 M) to 226Ra2+ (2.9 × 10-8 M) and at a 100-fold salt to ionophore excess. In the case of the G 1-picrate assembly, more competition was observed from Sr2+ and Ba2+, as extraction of 226Ra2+ ceased at an M2+/226Ra2+ ratio of 106 and 104, respectively. With the isoG 2 assembly, 226Ra2+ extraction also occurred at a Sr2+/226Ra2+ ratio of 106 but ceased at a 106 excess of Ba2+. The results clearly demonstrate the power of molecular self-assembly for the construction of highly selective ionophores.

AB - The self-assembled guanosine (G 1)-based hexadecamers and isoguanosine (isoG 2)-based decamers are excellent 226Ra2+ selective ionophores even in the presence of excess alkali (Na+, K+, Rb+, and Cs+) and alkaline earth (Mg2+, Ca2+, Sr2+, and Ba2+) cations over the pH range 3-11. G 1 requires additional picrate anions to provide a neutral assembly, whereas the isoG 2 assembly extracts 226Ra2+ cations without any such additives. Both G 1-picrate and isoG 2 assemblies show 226Ra2+ extraction even at a 0.35 × 106 fold excess of Na+, K+, Rb+, Cs+, Mg2+, or Ca2+ (10-2 M) to 226Ra2+ (2.9 × 10-8 M) and at a 100-fold salt to ionophore excess. In the case of the G 1-picrate assembly, more competition was observed from Sr2+ and Ba2+, as extraction of 226Ra2+ ceased at an M2+/226Ra2+ ratio of 106 and 104, respectively. With the isoG 2 assembly, 226Ra2+ extraction also occurred at a Sr2+/226Ra2+ ratio of 106 but ceased at a 106 excess of Ba2+. The results clearly demonstrate the power of molecular self-assembly for the construction of highly selective ionophores.

KW - METIS-222226

KW - IR-49601

U2 - 10.1021/ja0455650 S0002-7863(04)05565-9

DO - 10.1021/ja0455650 S0002-7863(04)05565-9

M3 - Article

VL - 126

SP - 16575

EP - 16581

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 50

ER -