Selective antifungal activity of silver nanoparticles: A comparative study between Candida tropicalis and Saccharomyces boulardii

Jesus D. Guerra, Georgina Sandoval*, Miguel Avalos-Borja, A. Pestryakov, Diana Garibo, Arturo Susarrey Arce, N. Bogdanchikova*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In this study, the antifungal activity of AgNPs was tested against C. tropicalis (pathogen fungi) and S. boulardii (probiotic). The effectiveness of the AgNPs was assessed by comparing their antifungal activity with a triazole antifungal drug fluconazole and amphotericin B. The AgNPs have a polygonal-like shape (average size of 35 ± 15 nm) with 1.2% wt. of metallic silver stabilized with 18.8% wt. of polyvinylpyrrolidone (PVP) in 80% wt. of distilled water. The results revealed that 35 μg/mL of fluconazole inhibits 55–60% of both fungal cell growth. As for amphotericin B, 5 μg/mL is sufficient to inhibit more than 95% of both fungal cells. For AgNPs, 25 μg/mL was needed to inhibit 90% of the C. tropicalis cell growth, but remarkably, 50% of the S. boulardii cell population remains viable, which can potentiate cell reproduction. Our results could initiate the development of AgNPs possessing selective specificity against pathogenic fungal species.
Original languageEnglish
Article number100280
JournalColloids and Interface Science Communications
Volume37
Early online date12 Jun 2020
DOIs
Publication statusPublished - Jul 2020

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