Selective Extraction of Xylose from Acidic Hydrolysate-from Fundamentals to Process

Luca Ricciardi, Willem Verboom*, Jean Paul Lange*, Jurriaan Huskens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
126 Downloads (Pure)


Xylose is a promising feedstock for the fuel and chemical industry. We propose here an integrated process to recover and purify xylose from an acidic hydrolysate stream, e.g., coming from pretreated lignocellulose. This process consists of selectively extracting the xylose as the diboronate ester and back-extracting it into a clean aqueous solution. We report 85% xylose extraction efficiency using toluene/phenyl boronic acid in a single stage. We show that the extraction procedure is compatible with acidic and basic xylose feed (from pH 1 to 12), does not need a phase transfer agent (such as Aliquat), is strongly selective for xylose, and proceeds best with aromatic solvents. We demonstrate the structure of the diboronate ester by means of 2D-NMR and show evidence for the intermediate formation of a monoboronate ester. The release of xylose from the diboronate ester is explored, and an integrated process for xylose purification is proposed and its boundaries are discussed.

Original languageEnglish
Pages (from-to)6632-6638
Number of pages7
JournalACS Sustainable Chemistry and Engineering
Issue number19
Early online date6 May 2021
Publication statusPublished - 17 May 2021


  • UT-Hybrid-D
  • Boronic acid
  • Extraction
  • Pentose
  • Recovery
  • Sugar
  • Boronate ester


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