Selective functionalization of calix[6]arenes at the upper rim

Javier de Mendoza, Mar Carramolino, Felix Cuevas, Pedro M. Nieto, Pilar Prados, David Reinhoudt

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    Abstract

    Methylation of partially O-benzylated p-tert-butylcalix[6]arenes followed by hydrogenolysis constitutes an efficient method for the preparation of partially O-alkylated Calix[6]arenes in gram amounts, without adhering to column chromatography separations. Selective de-tert-butylation followed by halogenation, or ipso-nitration of these precursors affords Calix[6]arenes containing bromo- or nitrosubstituents, respectively, at precise positions of the upper rim.
    Original languageUndefined
    Pages (from-to)47-50
    JournalSynthesis (Germany)
    Volume1994
    Issue number1
    DOIs
    Publication statusPublished - 1994

    Keywords

    • METIS-106664
    • IR-12440

    Cite this

    de Mendoza, J., Carramolino, M., Cuevas, F., Nieto, P. M., Prados, P., & Reinhoudt, D. (1994). Selective functionalization of calix[6]arenes at the upper rim. Synthesis (Germany), 1994(1), 47-50. https://doi.org/10.1055/s-1994-25403