Selective functionalization of calix[6]arenes at the upper rim

Javier de Mendoza, Mar Carramolino, Felix Cuevas, Pedro M. Nieto, Pilar Prados, David Reinhoudt

    Research output: Contribution to journalArticleAcademic

    32 Citations (Scopus)
    122 Downloads (Pure)


    Methylation of partially O-benzylated p-tert-butylcalix[6]arenes followed by hydrogenolysis constitutes an efficient method for the preparation of partially O-alkylated Calix[6]arenes in gram amounts, without adhering to column chromatography separations. Selective de-tert-butylation followed by halogenation, or ipso-nitration of these precursors affords Calix[6]arenes containing bromo- or nitrosubstituents, respectively, at precise positions of the upper rim.
    Original languageUndefined
    Pages (from-to)47-50
    JournalSynthesis (Germany)
    Issue number1
    Publication statusPublished - 1994


    • METIS-106664
    • IR-12440

    Cite this