Selective stimulation of the subthalamic nucleus

D.G.M Zwartjes - de Klerk

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

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Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder. In 2008, about 30.000 PD patients were registered at hospitals in the Netherlands. The number of PD patients is expected to increase by 47% from 2005 to 2025. PD is characterized by several motor related symptoms including tremor, bradykinesia, i.e. reduced movement speed and amplitude, hypokinesia, i.e. poverty of movement, episodes of freezing, impaired balance and postural control, dyskinesia, i.e. overactivity of muscles, rigidity, and adaptive responses. In the initial stage, PD is usually treated with Levodopa. This treatment is often very effective, but the efficacy of levodopa drops with time. The disease progressively becomes more severe and therefore it becomes increasingly difficult to treat in advanced stages. Surgical treatment in PD is usually employed when the patient responds well to medication, but experiences motor fluctuations and intolerable side effects as a result of high dosages.
Original languageUndefined
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Veltink, Petrus H., Supervisor
  • Heida, Tjitske , Advisor
Thesis sponsors
Award date31 May 2013
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-35304
DOIs
Publication statusPublished - 31 May 2013

Keywords

  • IR-86133
  • EWI-23377
  • Subthalamic nucleus
  • METIS-296523
  • BSS-Electrical Neurostimulation
  • parkinson
  • selective stimulation
  • Deep Brain Stimulation

Cite this

Zwartjes - de Klerk, D. G. M. (2013). Selective stimulation of the subthalamic nucleus. Enschede: University of Twente. https://doi.org/10.3990/1.9789036535304
Zwartjes - de Klerk, D.G.M. / Selective stimulation of the subthalamic nucleus. Enschede : University of Twente, 2013. 170 p.
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title = "Selective stimulation of the subthalamic nucleus",
abstract = "Parkinson's disease (PD) is the second most common neurodegenerative disorder. In 2008, about 30.000 PD patients were registered at hospitals in the Netherlands. The number of PD patients is expected to increase by 47{\%} from 2005 to 2025. PD is characterized by several motor related symptoms including tremor, bradykinesia, i.e. reduced movement speed and amplitude, hypokinesia, i.e. poverty of movement, episodes of freezing, impaired balance and postural control, dyskinesia, i.e. overactivity of muscles, rigidity, and adaptive responses. In the initial stage, PD is usually treated with Levodopa. This treatment is often very effective, but the efficacy of levodopa drops with time. The disease progressively becomes more severe and therefore it becomes increasingly difficult to treat in advanced stages. Surgical treatment in PD is usually employed when the patient responds well to medication, but experiences motor fluctuations and intolerable side effects as a result of high dosages.",
keywords = "IR-86133, EWI-23377, Subthalamic nucleus, METIS-296523, BSS-Electrical Neurostimulation, parkinson, selective stimulation, Deep Brain Stimulation",
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day = "31",
doi = "10.3990/1.9789036535304",
language = "Undefined",
isbn = "978-90-365-35304",
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Zwartjes - de Klerk, DGM 2013, 'Selective stimulation of the subthalamic nucleus', University of Twente, Enschede. https://doi.org/10.3990/1.9789036535304

Selective stimulation of the subthalamic nucleus. / Zwartjes - de Klerk, D.G.M.

Enschede : University of Twente, 2013. 170 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

TY - THES

T1 - Selective stimulation of the subthalamic nucleus

AU - Zwartjes - de Klerk, D.G.M

PY - 2013/5/31

Y1 - 2013/5/31

N2 - Parkinson's disease (PD) is the second most common neurodegenerative disorder. In 2008, about 30.000 PD patients were registered at hospitals in the Netherlands. The number of PD patients is expected to increase by 47% from 2005 to 2025. PD is characterized by several motor related symptoms including tremor, bradykinesia, i.e. reduced movement speed and amplitude, hypokinesia, i.e. poverty of movement, episodes of freezing, impaired balance and postural control, dyskinesia, i.e. overactivity of muscles, rigidity, and adaptive responses. In the initial stage, PD is usually treated with Levodopa. This treatment is often very effective, but the efficacy of levodopa drops with time. The disease progressively becomes more severe and therefore it becomes increasingly difficult to treat in advanced stages. Surgical treatment in PD is usually employed when the patient responds well to medication, but experiences motor fluctuations and intolerable side effects as a result of high dosages.

AB - Parkinson's disease (PD) is the second most common neurodegenerative disorder. In 2008, about 30.000 PD patients were registered at hospitals in the Netherlands. The number of PD patients is expected to increase by 47% from 2005 to 2025. PD is characterized by several motor related symptoms including tremor, bradykinesia, i.e. reduced movement speed and amplitude, hypokinesia, i.e. poverty of movement, episodes of freezing, impaired balance and postural control, dyskinesia, i.e. overactivity of muscles, rigidity, and adaptive responses. In the initial stage, PD is usually treated with Levodopa. This treatment is often very effective, but the efficacy of levodopa drops with time. The disease progressively becomes more severe and therefore it becomes increasingly difficult to treat in advanced stages. Surgical treatment in PD is usually employed when the patient responds well to medication, but experiences motor fluctuations and intolerable side effects as a result of high dosages.

KW - IR-86133

KW - EWI-23377

KW - Subthalamic nucleus

KW - METIS-296523

KW - BSS-Electrical Neurostimulation

KW - parkinson

KW - selective stimulation

KW - Deep Brain Stimulation

U2 - 10.3990/1.9789036535304

DO - 10.3990/1.9789036535304

M3 - PhD Thesis - Research UT, graduation UT

SN - 978-90-365-35304

PB - University of Twente

CY - Enschede

ER -

Zwartjes - de Klerk DGM. Selective stimulation of the subthalamic nucleus. Enschede: University of Twente, 2013. 170 p. https://doi.org/10.3990/1.9789036535304