Self-assembly and photo-cross-linking of eight-armed PEG-PTMC star block copolymers

Sytze J. Buwalda; Laura B. Perez; Sandra G. Perez; Sandra Teixeira; Lucia Calucci; Claudia Forte; Jan Feijen; Pieter J. Dijkstra

doi:10.1021/bm200515h

Self-assembly and photo-cross-linking of eight-armed PEG-PTMC star block copolymers

Sytze J. Buwalda, Laura B. Perez, Sandra G. Perez, Sandra Teixeira, Lucia Calucci, Claudia Forte, Jan Feijen, Pieter J. Dijkstra

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Eight-armed poly(ethylene glycol)-poly(trimethylene carbonate) star block copolymers (PEG-(PTMC)8) linked by a carbamate group between the PEG core and the PTMC blocks were synthesized by the metal-free, HCl-catalyzed ring-opening polymerization of trimethylene carbonate using an amine-terminated eight-armed star PEG in dichloromethane. Although dye solubilization experiments, nuclear magnetic resonance spectroscopy, and dynamic light scattering clearly indicated the presence of aggregates in aqueous dispersions of the copolymers, no physical gelation was observed up to high concentrations. PEG-(PTMC9)8 was end-group-functionalized using acryloyl chloride and photopolymerized in the presence of Irgacure 2959. When dilute aqueous dispersions of PEG-(PTMC9)8-Acr were UV irradiated, chemically cross-linked PEG-PTMC nanoparticles were obtained, whereas irradiation of more concentrated PEG-(PTMC9)8-Acr dispersions resulted in the formation of photo-cross-linked hydrogels. Their good mechanical properties and high stability against hydrolytic degradation make photo-cross-linked PEG-PTMC hydrogels interesting for biomedical applications such as matrices for tissue engineering and controlled drug delivery systems.

Original language	English
Pages (from-to)	2746-2754
Journal	Biomacromolecules
Volume	12
Issue number	7
DOIs	https://doi.org/10.1021/bm200515h
Publication status	Published - 2011

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@article{d473dcd3d9cd4ad09e0f7bae5319d5de,

title = "Self-assembly and photo-cross-linking of eight-armed PEG-PTMC star block copolymers",

abstract = "Eight-armed poly(ethylene glycol)-poly(trimethylene carbonate) star block copolymers (PEG-(PTMC)8) linked by a carbamate group between the PEG core and the PTMC blocks were synthesized by the metal-free, HCl-catalyzed ring-opening polymerization of trimethylene carbonate using an amine-terminated eight-armed star PEG in dichloromethane. Although dye solubilization experiments, nuclear magnetic resonance spectroscopy, and dynamic light scattering clearly indicated the presence of aggregates in aqueous dispersions of the copolymers, no physical gelation was observed up to high concentrations. PEG-(PTMC9)8 was end-group-functionalized using acryloyl chloride and photopolymerized in the presence of Irgacure 2959. When dilute aqueous dispersions of PEG-(PTMC9)8-Acr were UV irradiated, chemically cross-linked PEG-PTMC nanoparticles were obtained, whereas irradiation of more concentrated PEG-(PTMC9)8-Acr dispersions resulted in the formation of photo-cross-linked hydrogels. Their good mechanical properties and high stability against hydrolytic degradation make photo-cross-linked PEG-PTMC hydrogels interesting for biomedical applications such as matrices for tissue engineering and controlled drug delivery systems.",

author = "Buwalda, {Sytze J.} and Perez, {Laura B.} and Perez, {Sandra G.} and Sandra Teixeira and Lucia Calucci and Claudia Forte and Jan Feijen and Dijkstra, {Pieter J.}",

year = "2011",

doi = "10.1021/bm200515h",

language = "English",

volume = "12",

pages = "2746--2754",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

number = "7",

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TY - JOUR

T1 - Self-assembly and photo-cross-linking of eight-armed PEG-PTMC star block copolymers

AU - Buwalda, Sytze J.

AU - Perez, Laura B.

AU - Perez, Sandra G.

AU - Teixeira, Sandra

AU - Calucci, Lucia

AU - Forte, Claudia

AU - Feijen, Jan

AU - Dijkstra, Pieter J.

PY - 2011

Y1 - 2011

N2 - Eight-armed poly(ethylene glycol)-poly(trimethylene carbonate) star block copolymers (PEG-(PTMC)8) linked by a carbamate group between the PEG core and the PTMC blocks were synthesized by the metal-free, HCl-catalyzed ring-opening polymerization of trimethylene carbonate using an amine-terminated eight-armed star PEG in dichloromethane. Although dye solubilization experiments, nuclear magnetic resonance spectroscopy, and dynamic light scattering clearly indicated the presence of aggregates in aqueous dispersions of the copolymers, no physical gelation was observed up to high concentrations. PEG-(PTMC9)8 was end-group-functionalized using acryloyl chloride and photopolymerized in the presence of Irgacure 2959. When dilute aqueous dispersions of PEG-(PTMC9)8-Acr were UV irradiated, chemically cross-linked PEG-PTMC nanoparticles were obtained, whereas irradiation of more concentrated PEG-(PTMC9)8-Acr dispersions resulted in the formation of photo-cross-linked hydrogels. Their good mechanical properties and high stability against hydrolytic degradation make photo-cross-linked PEG-PTMC hydrogels interesting for biomedical applications such as matrices for tissue engineering and controlled drug delivery systems.

AB - Eight-armed poly(ethylene glycol)-poly(trimethylene carbonate) star block copolymers (PEG-(PTMC)8) linked by a carbamate group between the PEG core and the PTMC blocks were synthesized by the metal-free, HCl-catalyzed ring-opening polymerization of trimethylene carbonate using an amine-terminated eight-armed star PEG in dichloromethane. Although dye solubilization experiments, nuclear magnetic resonance spectroscopy, and dynamic light scattering clearly indicated the presence of aggregates in aqueous dispersions of the copolymers, no physical gelation was observed up to high concentrations. PEG-(PTMC9)8 was end-group-functionalized using acryloyl chloride and photopolymerized in the presence of Irgacure 2959. When dilute aqueous dispersions of PEG-(PTMC9)8-Acr were UV irradiated, chemically cross-linked PEG-PTMC nanoparticles were obtained, whereas irradiation of more concentrated PEG-(PTMC9)8-Acr dispersions resulted in the formation of photo-cross-linked hydrogels. Their good mechanical properties and high stability against hydrolytic degradation make photo-cross-linked PEG-PTMC hydrogels interesting for biomedical applications such as matrices for tissue engineering and controlled drug delivery systems.

U2 - 10.1021/bm200515h

DO - 10.1021/bm200515h

M3 - Article

SN - 1525-7797

VL - 12

SP - 2746

EP - 2754

JO - Biomacromolecules

JF - Biomacromolecules

IS - 7

ER -

Self-assembly and photo-cross-linking of eight-armed PEG-PTMC star block copolymers

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