Self-Assembly of Proteins: Towards Supramolecular Materials

Liulin Yang, Aijie Liu, Shuqin Cao, Rindia M. Putri, Pascal Jonkheijm*, Jeroen J.L.M. Cornelissen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)
52 Downloads (Pure)

Abstract

The study of protein self-assembly has attracted great interest over the decades, due to the important role that proteins play in life. In contrast to the major achievements that have been made in the fields of DNA origami, RNA, and synthetic peptides, methods for the design of self-assembling proteins have progressed more slowly. This Concept article provides a brief overview of studies on native protein and artificial scaffold assemblies and highlights advances in designing self-assembling proteins. The discussions are focused on design strategies for self-assembling proteins, including protein fusion, chemical conjugation, supramolecular, and computational-aided de novo design.
Original languageEnglish
Pages (from-to)15570-15582
Number of pages12
JournalChemistry : a European journal
Volume22
Issue number44
DOIs
Publication statusPublished - 2016

Keywords

  • 2023 OA procedure

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