Semi-anthropomorphic photoacoustic breast phantom

Maura Dantuma*, Rianne van Dommelen, Srirang Manohar

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Imaging parameters of photoacoustic breast imaging systems such as the spatial resolution and imaging depth are often characterized with phantoms. These objects usually contain simple structures in homogeneous media such as absorbing wires or spherical objects in scattering gels. While these kinds of basic phantoms are uncluttered and useful, they do not challenge the system as much as a breast does, and can thereby overestimate the system’s performance. The female breast is a complex collection of tissue types, and the acoustic and optical attenuation of these tissues limit the imaging depth, the resolution and the ability to extract quantitative information. For testing and challenging photoacoustic breast imaging systems to the full extent before moving to in vivo studies, a complex breast phantom which simulates the breast’s most prevalent tissues is required. In this work we present the first three dimensional multi-layered semi-anthropomorphic photoacoustic breast phantom. The phantom aims to simulate skin, fat, fibroglandular tissue and blood vessels. The latter three are made from custom polyvinyl chloride plastisol (PVCP) formulations and are appropriately doped with additives to obtain tissue realistic acoustic and optical properties. Two tumors are embedded, which are modeled as clusters of small blood vessels. The PVCP materials are surrounded by a silicon layer mimicking the skin. The tissue mimicking materials were cast into the shapes and sizes expected in the breast using 3D-printed moulds developed from a magnetic resonance imaging segmented numerical breast model. The various structures and layers were assembled to obtain a realistic breast morphology. We demonstrate the phantom’s appearance in both ultrasound imaging as photoacoustic tomography and make a comparison with a photoacoustic image of a real breast. A good correspondence is observed, which confirms the phantom’s usefulness.
Original languageEnglish
Pages (from-to)5921-5939
Number of pages19
JournalBiomedical optics express
Volume10
Issue number11
Early online date20 Sep 2019
DOIs
Publication statusPublished - 29 Oct 2019

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breast
Breast
plastisols
polyvinyl chloride
blood vessels
Polyvinyl Chloride
Acoustics
Blood Vessels
acoustic attenuation
Skin
acoustic properties
fats
Silicon
vessels
magnetic resonance
casts
Ultrasonography
Fungi
tumors
tomography

Cite this

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Semi-anthropomorphic photoacoustic breast phantom. / Dantuma, Maura ; van Dommelen, Rianne; Manohar, Srirang .

In: Biomedical optics express, Vol. 10, No. 11, 29.10.2019, p. 5921-5939.

Research output: Contribution to journalArticleAcademicpeer-review

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