Sensitivity and selectivity of intraneural stimulation using a silicon electrode array

Wim Rutten, Harmen J. van Wier, Johan H.M. Put, J.H.M. Put

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Abstract

A multielectrode array in silicon technology, as well as experimental paradigms and model calculations for sensitivity and selectivity measures, have been developed. The array consists of twelve platinum electrode sites (10×50 ¿m and 50 ¿m interdistance) on a 45-¿m thick tip-shaped silicon substrate and a Si3N 4 insulating glass cover layer. The tip is inserted in the peroneal nerve of a rat during acute experiments to stimulate ¿ motor fibers or the extensor digitorum longus muscle. Sensitivity calculations and experiments show a cubic dependence of the number of stimulated motor units on current amplitude of the stimulatory pulse (recruitment curves), starting at single motor level. Selectivity was tested by a method based on the refractory properties of neurons. At the lowest stimulus levels (for one motor unit) selectivity is maximal when two electrodes are separated by 200-250 ¿m, which was also estimated on theoretical grounds. The study provides clues for future designs of two- and three-dimensional devices
Original languageUndefined
Pages (from-to)192-198
Number of pages6
JournalIEEE transactions on biomedical engineering
Volume0
Issue number3
DOIs
Publication statusPublished - 1991

Keywords

  • METIS-112212
  • IR-15337

Cite this

Rutten, Wim ; van Wier, Harmen J. ; Put, Johan H.M. ; Put, J.H.M. / Sensitivity and selectivity of intraneural stimulation using a silicon electrode array. In: IEEE transactions on biomedical engineering. 1991 ; Vol. 0, No. 3. pp. 192-198.
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Sensitivity and selectivity of intraneural stimulation using a silicon electrode array. / Rutten, Wim; van Wier, Harmen J.; Put, Johan H.M.; Put, J.H.M.

In: IEEE transactions on biomedical engineering, Vol. 0, No. 3, 1991, p. 192-198.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - van Wier, Harmen J.

AU - Put, Johan H.M.

AU - Put, J.H.M.

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AB - A multielectrode array in silicon technology, as well as experimental paradigms and model calculations for sensitivity and selectivity measures, have been developed. The array consists of twelve platinum electrode sites (10×50 ¿m and 50 ¿m interdistance) on a 45-¿m thick tip-shaped silicon substrate and a Si3N 4 insulating glass cover layer. The tip is inserted in the peroneal nerve of a rat during acute experiments to stimulate ¿ motor fibers or the extensor digitorum longus muscle. Sensitivity calculations and experiments show a cubic dependence of the number of stimulated motor units on current amplitude of the stimulatory pulse (recruitment curves), starting at single motor level. Selectivity was tested by a method based on the refractory properties of neurons. At the lowest stimulus levels (for one motor unit) selectivity is maximal when two electrodes are separated by 200-250 ¿m, which was also estimated on theoretical grounds. The study provides clues for future designs of two- and three-dimensional devices

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