Sensitivity and selectivity of intraneural stimulation using a silicon electrode array

Wim Rutten, Harmen J. van Wier, Johan H.M. Put, J.H.M. Put

    Research output: Contribution to journalArticleAcademicpeer-review

    80 Citations (Scopus)
    89 Downloads (Pure)

    Abstract

    A multielectrode array in silicon technology, as well as experimental paradigms and model calculations for sensitivity and selectivity measures, have been developed. The array consists of twelve platinum electrode sites (10×50 ¿m and 50 ¿m interdistance) on a 45-¿m thick tip-shaped silicon substrate and a Si3N 4 insulating glass cover layer. The tip is inserted in the peroneal nerve of a rat during acute experiments to stimulate ¿ motor fibers or the extensor digitorum longus muscle. Sensitivity calculations and experiments show a cubic dependence of the number of stimulated motor units on current amplitude of the stimulatory pulse (recruitment curves), starting at single motor level. Selectivity was tested by a method based on the refractory properties of neurons. At the lowest stimulus levels (for one motor unit) selectivity is maximal when two electrodes are separated by 200-250 ¿m, which was also estimated on theoretical grounds. The study provides clues for future designs of two- and three-dimensional devices
    Original languageUndefined
    Pages (from-to)192-198
    Number of pages6
    JournalIEEE transactions on biomedical engineering
    Volume0
    Issue number3
    DOIs
    Publication statusPublished - 1991

    Keywords

    • METIS-112212
    • IR-15337

    Cite this