Separation of superparamagnetic particles through ratcheted Brownian motion and periodically switching magnetic fields

Fan Liu, Li Jiang, Huei Ming Tan, Ashutosh Yadav, Preetika Biswas, Johan R. C. van der Maarel, Christian A. Nijhuis, Jeroen A. van Kan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

ABSTRACTBrownian ratchet based particle separation systems for application in lab on chip devices have drawn interest and are subject to ongoing theoretical and experimental investigations. We demonstrate a compact microfluidic particle separation chip, which implements an extended on-off Brownian ratchet scheme that actively separates and sorts particles using periodically switching magnetic fields, asymmetric sawtooth channel sidewalls, and Brownian motion. The microfluidic chip was made with Polydimethylsiloxane (PDMS) soft lithography of SU-8 molds, which in turn was fabricated using Proton Beam Writing. After bonding of the PDMS chip to a glass substrate through surface activation by oxygen plasma treatment, embedded electromagnets were cofabricated by the injection of InSn metal into electrode channels. This fabrication process enables rapid production of high resolution and high aspect ratio features, which results in parallel electrodes accurately aligned with respect to the separation channel. The PDMS devices were tested with mixtures of 1.51 μm, 2.47 μm, and 2.60 μm superparamagnetic particles suspended in water. Experimental results show that the current device design has potential for separating particles with a size difference around 130 nm. Based on the promising results, we will be working towards extending this design for the separation of cells or biomolecules.
Original languageEnglish
Article number064105
JournalBiomicrofluidics
Volume10
Issue number6
DOIs
Publication statusPublished - Nov 2016
Externally publishedYes

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