Serial intravascular ultrasound assessment of changes in coronary atherosclerotic plaque dimensions and composition: an update

Marc Hartmann, Jennifer Huisman, Dirk Böse, Lisette O. Jensen, Paul Schoenhagen, Gary S. Mintz, Raimund Erbel, Clemens von Birgelen

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Abstract

This manuscript reviews the use of serial intravascular ultrasound (IVUS) examination of coronary atherosclerosis in recent observational studies and randomized trials that revealed the effects of cholesterol-lowering and lipid-modifying therapies and offered novel insight into plaque progression and regression. We discuss the value of plaque progression–regression as complementary imaging endpoint and potential surrogate marker of cardiovascular event risk. In addition, the progress in serial assessment of coronary plaque composition and plaque vulnerability by radiofrequency-based analyses is reviewed. Finally, we report on the evaluation of true vessel remodelling in recent serial IVUS trials and discuss the future perspective of serial invasive imaging of coronary atherosclerosis.
Original languageEnglish
Pages (from-to)313-321
Number of pages9
JournalEuropean journal of echocardiography
Volume12
Issue number4
DOIs
Publication statusPublished - 2011

Keywords

  • METIS-280519
  • IR-104565
  • Coronary disease
  • Intravascular ultrasound
  • Radiofrequency
  • Serial studies
  • Progression–regression
  • Plaque vulnerability

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