Abstract
Magnetic nanoparticles (MNPs) are used in many biomedical applications, including sentinel lymph node biopsy (SLNB) and magnetic particle imaging (MPI). University of Twente has developed DiffMag handheld probe for a magnetic SLNB utilising MNPs. This probe is based upon differential magnetometry employing nonlinear magnetic response of superparamagnetic MNPs. The DiffMag handheld probe consists of an excitation coil to activate the MNPs, and a set of detection coils to acquire the signal generated by MNPs. The hydrodynamic size and surface properties of MNPs may change when introduced to a new environment. This alteration in mechanical properties will have an effect on their magnetic behaviour. In this study, the protocol settings for the nonlinear handheld detection probe during the SLNB procedure is optimized. The observed detection depth of DiffMag handheld probe decreases slightly by increasing the environment viscosity.
Original language | English |
---|---|
Article number | 2303052 |
Journal | International Journal on Magnetic Particle Imaging |
Volume | 9 |
Issue number | 1, suppl. 1 |
DOIs | |
Publication status | Published - 19 Mar 2023 |