Settings of DiffMag handheld probe for maximal detection depth aiming perioperative lymph node harvesting

S. Salamzadeh, H.J.G. Krooshoop, B. ten Haken, L. Alic*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Magnetic nanoparticles (MNPs) are used in many biomedical applications, including sentinel lymph node biopsy (SLNB) and magnetic particle imaging (MPI). University of Twente has developed DiffMag handheld probe for a magnetic SLNB utilising MNPs. This probe is based upon differential magnetometry employing nonlinear magnetic response of superparamagnetic MNPs. The DiffMag handheld probe consists of an excitation coil to activate the MNPs, and a set of detection coils to acquire the signal generated by MNPs. The hydrodynamic size and surface properties of MNPs may change when introduced to a new environment. This alteration in mechanical properties will have an effect on their magnetic behaviour. In this study, the protocol settings for the nonlinear handheld detection probe during the SLNB procedure is optimized. The observed detection depth of DiffMag handheld probe decreases slightly by increasing the environment viscosity.

Original languageEnglish
Article number2303052
JournalInternational Journal on Magnetic Particle Imaging
Volume9
Issue number1, suppl. 1
DOIs
Publication statusPublished - 19 Mar 2023

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