Shaping membranes with disordered proteins

Mohammad A.A. Fakhree; Christian Blum; Mireille M.A.E. Claessens

doi:10.1016/j.abb.2019.108163

Shaping membranes with disordered proteins

Mohammad A.A. Fakhree, Christian Blum, Mireille M.A.E. Claessens^*

^*Corresponding author for this work

Nanobiophysics

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Membrane proteins control and shape membrane trafficking processes. The role of protein structure in shaping cellular membranes is well established. However, a significant fraction of membrane proteins is disordered or contains long disordered regions. It becomes more and more clear that these disordered regions contribute to the function of membrane proteins. While the fold of a structured protein is essential for its function, being disordered seems to be a crucial feature of membrane bound intrinsically disordered proteins and protein regions. Here we outline the motifs that encode function in disordered proteins and discuss how these functional motifs enable disordered proteins to modulate membrane properties. These changes in membrane properties facilitate and regulate membrane trafficking processes which are highly abundant in eukaryotes.

Original language	English
Article number	108163
Journal	Archives of biochemistry and biophysics
Volume	677
Early online date	29 Oct 2019
DOIs	https://doi.org/10.1016/j.abb.2019.108163
Publication status	Published - 30 Nov 2019

Keywords

Disordered proteins
Membrane curvature
Membrane domains
Membrane tethering
Membranes

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10.1016/j.abb.2019.108163Licence: CC BY

1-s2.0-S0003986119305776-mainFinal published version, 3.41 MBLicence: CC BY

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title = "Shaping membranes with disordered proteins",

abstract = "Membrane proteins control and shape membrane trafficking processes. The role of protein structure in shaping cellular membranes is well established. However, a significant fraction of membrane proteins is disordered or contains long disordered regions. It becomes more and more clear that these disordered regions contribute to the function of membrane proteins. While the fold of a structured protein is essential for its function, being disordered seems to be a crucial feature of membrane bound intrinsically disordered proteins and protein regions. Here we outline the motifs that encode function in disordered proteins and discuss how these functional motifs enable disordered proteins to modulate membrane properties. These changes in membrane properties facilitate and regulate membrane trafficking processes which are highly abundant in eukaryotes.",

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AB - Membrane proteins control and shape membrane trafficking processes. The role of protein structure in shaping cellular membranes is well established. However, a significant fraction of membrane proteins is disordered or contains long disordered regions. It becomes more and more clear that these disordered regions contribute to the function of membrane proteins. While the fold of a structured protein is essential for its function, being disordered seems to be a crucial feature of membrane bound intrinsically disordered proteins and protein regions. Here we outline the motifs that encode function in disordered proteins and discuss how these functional motifs enable disordered proteins to modulate membrane properties. These changes in membrane properties facilitate and regulate membrane trafficking processes which are highly abundant in eukaryotes.

KW - Disordered proteins

KW - Membrane curvature

KW - Membrane domains

KW - Membrane tethering

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M3 - Review article

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VL - 677

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Shaping membranes with disordered proteins

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