Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls

Jeanette C. Mostert, Martine Hoogman*, A. Marten H. Onnink, Daan van Rooij, Daniel von Rhein, Kimm J.E. van Hulzen, Janneke Dammers, Cornelis C. Kan, Jan K. Buitelaar, David G. Norris, Barbara Franke

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Objective: To characterize heterogeneity in adults with ADHD we aimed to identify subgroups within the adult ADHD spectrum, which differ in their cognitive profile. Method: Neuropsychological data from adults with ADHD (n = 133) and healthy control participants (n = 132) were used in a confirmatory factor analysis. The resulting six cognitive factors were correlated across participants to form networks. We used a community detection algorithm to cluster these networks into subgroups. Results: Both the ADHD and control group separated into three profiles that differed in cognitive performance. Profile 1 was characterized by aberrant attention and inhibition, profile 2 by increased delay discounting, and profile 3 by atypical working memory and verbal fluency. Conclusion: Our findings suggest that qualitative differences in neuropsychological performance exist in both control and ADHD adult individuals. This extends prior findings in children with and without ADHD and provides a framework to parse participants into well-defined subgroups.

Original languageEnglish
Pages (from-to)281-292
Number of pages12
JournalJournal of Attention Disorders
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Feb 2018
Externally publishedYes

Keywords

  • adult ADHD
  • delay discounting
  • executive functions
  • heterogeneity
  • neuropsychology

Fingerprint Dive into the research topics of 'Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls'. Together they form a unique fingerprint.

  • Cite this

    Mostert, J. C., Hoogman, M., Onnink, A. M. H., van Rooij, D., von Rhein, D., van Hulzen, K. J. E., ... Franke, B. (2018). Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls. Journal of Attention Disorders, 22(3), 281-292. https://doi.org/10.1177/1087054715602332