Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls

Jeanette C. Mostert; Martine Hoogman; A. Marten H. Onnink; Daan van Rooij; Daniel von Rhein; Kimm J.E. van Hulzen; Janneke Dammers; Cornelis C. Kan; Jan K. Buitelaar; David G. Norris; Barbara Franke

doi:10.1177/1087054715602332

Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls

Jeanette C. Mostert
, Martine Hoogman^*
, A. Marten H. Onnink
, Daan van Rooij
, Daniel von Rhein
, Kimm J.E. van Hulzen
, Janneke Dammers
, Cornelis C. Kan
, Jan K. Buitelaar
, David G. Norris
, Barbara Franke

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Scopus)

Abstract

Objective: To characterize heterogeneity in adults with ADHD we aimed to identify subgroups within the adult ADHD spectrum, which differ in their cognitive profile. Method: Neuropsychological data from adults with ADHD (n = 133) and healthy control participants (n = 132) were used in a confirmatory factor analysis. The resulting six cognitive factors were correlated across participants to form networks. We used a community detection algorithm to cluster these networks into subgroups. Results: Both the ADHD and control group separated into three profiles that differed in cognitive performance. Profile 1 was characterized by aberrant attention and inhibition, profile 2 by increased delay discounting, and profile 3 by atypical working memory and verbal fluency. Conclusion: Our findings suggest that qualitative differences in neuropsychological performance exist in both control and ADHD adult individuals. This extends prior findings in children with and without ADHD and provides a framework to parse participants into well-defined subgroups.

Original language	English
Pages (from-to)	281-292
Number of pages	12
Journal	Journal of Attention Disorders
Volume	22
Issue number	3
DOIs	https://doi.org/10.1177/1087054715602332
Publication status	Published - 1 Feb 2018
Externally published	Yes

Keywords

adult ADHD
delay discounting
executive functions
heterogeneity
neuropsychology

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Mostert, J. C., Hoogman, M., Onnink, A. M. H., van Rooij, D., von Rhein, D., van Hulzen, K. J. E., Dammers, J., Kan, C. C., Buitelaar, J. K., Norris, D. G., & Franke, B. (2018). Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls. Journal of Attention Disorders, 22(3), 281-292. https://doi.org/10.1177/1087054715602332

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title = "Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls",

abstract = "Objective: To characterize heterogeneity in adults with ADHD we aimed to identify subgroups within the adult ADHD spectrum, which differ in their cognitive profile. Method: Neuropsychological data from adults with ADHD (n = 133) and healthy control participants (n = 132) were used in a confirmatory factor analysis. The resulting six cognitive factors were correlated across participants to form networks. We used a community detection algorithm to cluster these networks into subgroups. Results: Both the ADHD and control group separated into three profiles that differed in cognitive performance. Profile 1 was characterized by aberrant attention and inhibition, profile 2 by increased delay discounting, and profile 3 by atypical working memory and verbal fluency. Conclusion: Our findings suggest that qualitative differences in neuropsychological performance exist in both control and ADHD adult individuals. This extends prior findings in children with and without ADHD and provides a framework to parse participants into well-defined subgroups.",

keywords = "adult ADHD, delay discounting, executive functions, heterogeneity, neuropsychology",

author = "Mostert, \{Jeanette C.\} and Martine Hoogman and Onnink, \{A. Marten H.\} and \{van Rooij\}, Daan and \{von Rhein\}, Daniel and \{van Hulzen\}, \{Kimm J.E.\} and Janneke Dammers and Kan, \{Cornelis C.\} and Buitelaar, \{Jan K.\} and Norris, \{David G.\} and Barbara Franke",

year = "2018",

month = feb,

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doi = "10.1177/1087054715602332",

language = "English",

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journal = "Journal of Attention Disorders",

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T1 - Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls

AU - Mostert, Jeanette C.

AU - Hoogman, Martine

AU - Onnink, A. Marten H.

AU - van Rooij, Daan

AU - von Rhein, Daniel

AU - van Hulzen, Kimm J.E.

AU - Dammers, Janneke

AU - Kan, Cornelis C.

AU - Buitelaar, Jan K.

AU - Norris, David G.

AU - Franke, Barbara

PY - 2018/2/1

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N2 - Objective: To characterize heterogeneity in adults with ADHD we aimed to identify subgroups within the adult ADHD spectrum, which differ in their cognitive profile. Method: Neuropsychological data from adults with ADHD (n = 133) and healthy control participants (n = 132) were used in a confirmatory factor analysis. The resulting six cognitive factors were correlated across participants to form networks. We used a community detection algorithm to cluster these networks into subgroups. Results: Both the ADHD and control group separated into three profiles that differed in cognitive performance. Profile 1 was characterized by aberrant attention and inhibition, profile 2 by increased delay discounting, and profile 3 by atypical working memory and verbal fluency. Conclusion: Our findings suggest that qualitative differences in neuropsychological performance exist in both control and ADHD adult individuals. This extends prior findings in children with and without ADHD and provides a framework to parse participants into well-defined subgroups.

AB - Objective: To characterize heterogeneity in adults with ADHD we aimed to identify subgroups within the adult ADHD spectrum, which differ in their cognitive profile. Method: Neuropsychological data from adults with ADHD (n = 133) and healthy control participants (n = 132) were used in a confirmatory factor analysis. The resulting six cognitive factors were correlated across participants to form networks. We used a community detection algorithm to cluster these networks into subgroups. Results: Both the ADHD and control group separated into three profiles that differed in cognitive performance. Profile 1 was characterized by aberrant attention and inhibition, profile 2 by increased delay discounting, and profile 3 by atypical working memory and verbal fluency. Conclusion: Our findings suggest that qualitative differences in neuropsychological performance exist in both control and ADHD adult individuals. This extends prior findings in children with and without ADHD and provides a framework to parse participants into well-defined subgroups.

KW - adult ADHD

KW - delay discounting

KW - executive functions

KW - heterogeneity

KW - neuropsychology

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DO - 10.1177/1087054715602332

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SN - 1087-0547

VL - 22

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EP - 292

JO - Journal of Attention Disorders

JF - Journal of Attention Disorders

IS - 3

ER -

Similar Subgroups Based on Cognitive Performance Parse Heterogeneity in Adults With ADHD and Healthy Controls

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