Simple and stable transendothelial electrical resistance measurement in organs-on-chips

Marieke Willemijn van der Helm, Mathieu Odijk, Jean-Philippe Frimat, Jan C.T. Eijkel, Albert van den Berg, Loes Irene Segerink

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)
2 Downloads (Pure)

Abstract

Measuring transendothelial electrical resistance (TEER) is a popular way to monitor cellular barrier tightness in organs-on-chips. However, in these devices integrated electrodes often block sight on the cells and the measured part often includes fluid-filled channels with variable resistance. Therefore, we redesigned our blood-brain barrier on a chip model to be able to measure stable TEER with four electrodes positioned outside the culture area using a simple impedance measurement setup
Original languageUndefined
Title of host publicationThe 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015)
PublisherChemical and Biological Micro Systems Society
Pages771-773
Number of pages3
ISBN (Print)978-0-9798064-8-3
Publication statusPublished - 25 Oct 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015 - Hwabaek International Convention Center (HICO), Gyeongju, Korea, Republic of
Duration: 25 Oct 201529 Oct 2015
Conference number: 19
http://www.rsc.org/images/LOC/2015/PDFs/Copyrite.pdf

Publication series

NameProceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS
PublisherChemical and Biological Microsystems Society
ISSN (Print)1556-5904

Conference

Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015
Abbreviated titleMicroTas 2015
CountryKorea, Republic of
CityGyeongju
Period25/10/1529/10/15
Internet address

Keywords

  • EWI-26552
  • IR-98702
  • METIS-315087

Cite this

van der Helm, M. W., Odijk, M., Frimat, J-P., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2015). Simple and stable transendothelial electrical resistance measurement in organs-on-chips. In The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015) (pp. 771-773). (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS). Chemical and Biological Micro Systems Society.
van der Helm, Marieke Willemijn ; Odijk, Mathieu ; Frimat, Jean-Philippe ; Eijkel, Jan C.T. ; van den Berg, Albert ; Segerink, Loes Irene. / Simple and stable transendothelial electrical resistance measurement in organs-on-chips. The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015). Chemical and Biological Micro Systems Society, 2015. pp. 771-773 (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS).
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abstract = "Measuring transendothelial electrical resistance (TEER) is a popular way to monitor cellular barrier tightness in organs-on-chips. However, in these devices integrated electrodes often block sight on the cells and the measured part often includes fluid-filled channels with variable resistance. Therefore, we redesigned our blood-brain barrier on a chip model to be able to measure stable TEER with four electrodes positioned outside the culture area using a simple impedance measurement setup",
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isbn = "978-0-9798064-8-3",
series = "Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS",
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van der Helm, MW, Odijk, M, Frimat, J-P, Eijkel, JCT, van den Berg, A & Segerink, LI 2015, Simple and stable transendothelial electrical resistance measurement in organs-on-chips. in The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015). Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS, Chemical and Biological Micro Systems Society, pp. 771-773, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015, Gyeongju, Korea, Republic of, 25/10/15.

Simple and stable transendothelial electrical resistance measurement in organs-on-chips. / van der Helm, Marieke Willemijn; Odijk, Mathieu; Frimat, Jean-Philippe; Eijkel, Jan C.T.; van den Berg, Albert; Segerink, Loes Irene.

The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015). Chemical and Biological Micro Systems Society, 2015. p. 771-773 (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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T1 - Simple and stable transendothelial electrical resistance measurement in organs-on-chips

AU - van der Helm, Marieke Willemijn

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AU - Frimat, Jean-Philippe

AU - Eijkel, Jan C.T.

AU - van den Berg, Albert

AU - Segerink, Loes Irene

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N2 - Measuring transendothelial electrical resistance (TEER) is a popular way to monitor cellular barrier tightness in organs-on-chips. However, in these devices integrated electrodes often block sight on the cells and the measured part often includes fluid-filled channels with variable resistance. Therefore, we redesigned our blood-brain barrier on a chip model to be able to measure stable TEER with four electrodes positioned outside the culture area using a simple impedance measurement setup

AB - Measuring transendothelial electrical resistance (TEER) is a popular way to monitor cellular barrier tightness in organs-on-chips. However, in these devices integrated electrodes often block sight on the cells and the measured part often includes fluid-filled channels with variable resistance. Therefore, we redesigned our blood-brain barrier on a chip model to be able to measure stable TEER with four electrodes positioned outside the culture area using a simple impedance measurement setup

KW - EWI-26552

KW - IR-98702

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SN - 978-0-9798064-8-3

T3 - Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS

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BT - The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015)

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van der Helm MW, Odijk M, Frimat J-P, Eijkel JCT, van den Berg A, Segerink LI. Simple and stable transendothelial electrical resistance measurement in organs-on-chips. In The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015). Chemical and Biological Micro Systems Society. 2015. p. 771-773. (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS).