Simple and stable transendothelial electrical resistance measurement in organs-on-chips

Marieke Willemijn van der Helm, Mathieu Odijk, Jean-Philippe Frimat, Jan C.T. Eijkel, Albert van den Berg, Loes Irene Segerink

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    1 Citation (Scopus)
    2 Downloads (Pure)

    Abstract

    Measuring transendothelial electrical resistance (TEER) is a popular way to monitor cellular barrier tightness in organs-on-chips. However, in these devices integrated electrodes often block sight on the cells and the measured part often includes fluid-filled channels with variable resistance. Therefore, we redesigned our blood-brain barrier on a chip model to be able to measure stable TEER with four electrodes positioned outside the culture area using a simple impedance measurement setup
    Original languageUndefined
    Title of host publicationThe 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015)
    PublisherChemical and Biological Micro Systems Society
    Pages771-773
    Number of pages3
    ISBN (Print)978-0-9798064-8-3
    Publication statusPublished - 25 Oct 2015
    Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015 - Hwabaek International Convention Center (HICO), Gyeongju, Korea, Republic of
    Duration: 25 Oct 201529 Oct 2015
    Conference number: 19
    http://www.rsc.org/images/LOC/2015/PDFs/Copyrite.pdf

    Publication series

    NameProceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS
    PublisherChemical and Biological Microsystems Society
    ISSN (Print)1556-5904

    Conference

    Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015
    Abbreviated titleMicroTas 2015
    CountryKorea, Republic of
    CityGyeongju
    Period25/10/1529/10/15
    Internet address

    Keywords

    • EWI-26552
    • IR-98702
    • METIS-315087

    Cite this

    van der Helm, M. W., Odijk, M., Frimat, J-P., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2015). Simple and stable transendothelial electrical resistance measurement in organs-on-chips. In The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015) (pp. 771-773). (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS). Chemical and Biological Micro Systems Society.