Simultaneous tracking of multiple nociceptive thresholds: a simulation and human subject study

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    Monte Carlo simulations were performed to compare bias, precision and bandwidth of thresh-old estimates while varying the number of simultaneous tracked thresholds (1-7). An adaptive random staircase procedure was used as stimulus selection procedure while logistic regression was used to obtain threshold estimates. We found that the bias was similar in all simulations. Moreover, precision and bandwidth lowered with more simultaneous tracked thresholds. Three different numbers of simultaneous tracked thresholds were compared in a human sub-ject study. A cold pressor was applied as nociceptive conditioning stimulus. Electrocutaneous stimulation was used for nociceptive detection threshold tracking before, during and after the conditioning stimulus.
    Original languageUndefined
    Title of host publicationFourth Dutch Bio-Medical Engineering Conference 2013
    Place of PublicationEgmond aan Zee
    Number of pages1
    ISBN (Print)not assigned
    Publication statusPublished - Jan 2013
    Event4th Dutch Bio-Medical Engineering Conference, BME 2013 - Hotel Zuiderduin, Egmond aan Zee, Netherlands
    Duration: 24 Jan 201325 Jan 2013
    Conference number: 4

    Publication series



    Conference4th Dutch Bio-Medical Engineering Conference, BME 2013
    Abbreviated titleBME
    CityEgmond aan Zee
    OtherFourth Dutch BME Conference
    Internet address


    • EWI-23270
    • BSS-Central mechanisms underlying chronic pain
    • Nociception
    • Pain
    • METIS-296400
    • IR-85976
    • Monte Carlo simulations
    • Psychophysics
    • human subjects

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