Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 3140-3155 |
| Number of pages | 16 |
| Journal | Clinical neurophysiology |
| Volume | 127 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 5 Jul 2016 |
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Keywords
- METIS-317484
- IR-100935
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Single and paired pulse transcranial magnetic stimulation in drug naïve epilepsy. / de Goede, Annika Aurora; Spanjer-ter Braack, Esther Maria; van Putten, Michel Johannes Antonius Maria.
In: Clinical neurophysiology, Vol. 127, No. 9, 05.07.2016, p. 3140-3155.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Single and paired pulse transcranial magnetic stimulation in drug naïve epilepsy
AU - de Goede, Annika Aurora
AU - Spanjer-ter Braack, Esther Maria
AU - van Putten, Michel Johannes Antonius Maria
PY - 2016/7/5
Y1 - 2016/7/5
N2 - Transcranial magnetic stimulation (TMS) measures cortical excitability and is therefore potentially suitable as an additional tool for epilepsy diagnostics and therapy evaluation. In this review we discuss the application of TMS in epilepsy research and systematically analyze single and paired pulse TMS outcomes from 31 drug naïve patient studies. Despite a large variety in used TMS protocols, there was no relation between specific protocol aspects and the occurrence of significant results. Protocols were often not in accordance with latest guidelines and recommendations. Cortical excitability, as measured by TMS, was increased in drug naïve epilepsy patients, being most prominent for generalized epilepsy. Single pulse TMS indicated a trend towards a lower resting motor threshold (rMT) and a prolonged cortical silent period (CSP) for generalized epilepsy, while inconclusive results were found for focal epilepsy. The paired pulse TMS outcomes, short intracortical inhibition (SICI) and long intracortical inhibition (LICI), showed the most consistent significant increase in cortical excitability in generalized and focal epilepsy patients. Future epilepsy research should especially focus on the interstimulus intervals 2 and 5 ms for SICI, and 250 and 300 ms for LICI. Furthermore, combining TMS with electroencephalography (EEG) may contribute to analysis on an individual patient level.
AB - Transcranial magnetic stimulation (TMS) measures cortical excitability and is therefore potentially suitable as an additional tool for epilepsy diagnostics and therapy evaluation. In this review we discuss the application of TMS in epilepsy research and systematically analyze single and paired pulse TMS outcomes from 31 drug naïve patient studies. Despite a large variety in used TMS protocols, there was no relation between specific protocol aspects and the occurrence of significant results. Protocols were often not in accordance with latest guidelines and recommendations. Cortical excitability, as measured by TMS, was increased in drug naïve epilepsy patients, being most prominent for generalized epilepsy. Single pulse TMS indicated a trend towards a lower resting motor threshold (rMT) and a prolonged cortical silent period (CSP) for generalized epilepsy, while inconclusive results were found for focal epilepsy. The paired pulse TMS outcomes, short intracortical inhibition (SICI) and long intracortical inhibition (LICI), showed the most consistent significant increase in cortical excitability in generalized and focal epilepsy patients. Future epilepsy research should especially focus on the interstimulus intervals 2 and 5 ms for SICI, and 250 and 300 ms for LICI. Furthermore, combining TMS with electroencephalography (EEG) may contribute to analysis on an individual patient level.
KW - METIS-317484
KW - IR-100935
U2 - 10.1016/j.clinph.2016.06.025
DO - 10.1016/j.clinph.2016.06.025
M3 - Review article
VL - 127
SP - 3140
EP - 3155
JO - Clinical neurophysiology
JF - Clinical neurophysiology
SN - 1388-2457
IS - 9
ER -