Modular bioinks based on single cell microgels within distinct injectable prepolymers enable uncoupling of biomaterials' micro- and macroenvironments. These inks allow biofabrication of 3D constructs that recapitulate the multiscale modular design of native tissues with a single cell resolution. This approach represents a major step forward in endowing engineered constructs with the multifunctionality that underlies the behavior of native tissues.
Kamperman, T., Henke, S. J., van den Berg, A., Shin, S. R., Tamayol, A., Khademhosseini, A., ... Leijten, J. C. H. (2017). Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macrenvironments. Advanced healthcare materials, 6(3), . https://doi.org/10.1002/adhm.201600913