Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy

Frédéric L.W.V.J. Schaper, Yan Zhao, Marcus L.F. Janssen, G. Louis Wagner, Albert J. Colon, Danny M.W. Hilkman, Erik Gommer, Mariëlle C.G. Vlooswijk, Govert Hoogland, Linda Ackermans, Lo J. Bour, Richard J.A. Van Wezel, Paul Boon, Yasin Temel, Tjitske Heida, Vivianne H.J.M. Van Kranen-Mastenbroek, Rob P.W. Rouhl (Corresponding Author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a promising treatment for patients with refractory epilepsy. However, therapy response varies and precise positioning of the DBS lead is potentially essential for maximizing therapeutic efficacy. We investigate if single-cell recordings acquired by microelectrode recordings can aid targeting of the ANT during surgery and hypothesize that the neuronal firing properties of the target region relate to clinical outcome. We prospectively included 10 refractory epilepsy patients and performed microelectrode recordings under general anesthesia to identify the change in neuronal signals when approaching and transecting the ANT. The neuronal firing properties of the target region, anatomical locations of microelectrode recordings and active contact positions of the DBS lead along the recorded trajectory were compared between responders and nonresponders to DBS. We obtained 19 sets of recordings from 10 patients (five responders and five nonresponders). Amongst the 403 neurons detected, 365 (90.6%) were classified as bursty. Entry into the ANT was characterized by an increase in firing rate while exit of the ANT was characterized by a decrease in firing rate. Comparing the trajectories of responders to nonresponders, we found differences neither in the neuronal firing properties themselves nor in their locations relative to the position of the active contact. Single-cell firing rate acquired by microelectrode recordings under general anesthesia can thus aid targeting of the ANT during surgery, but is not related to clinical outcome in DBS for patients with refractory epilepsy.

Original languageEnglish
JournalInternational journal of neural systems
DOIs
Publication statusAccepted/In press - 16 May 2018

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Refractory materials
Microelectrodes
Brain
Surgery
Trajectories
Neurons
Lead

Keywords

  • anterior nucleus of the thalamus
  • Deep brain stimulation
  • epilepsy
  • microelectrode recordings

Cite this

Schaper, F. L. W. V. J., Zhao, Y., Janssen, M. L. F., Wagner, G. L., Colon, A. J., Hilkman, D. M. W., ... Rouhl, R. P. W. (Accepted/In press). Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy. International journal of neural systems. https://doi.org/10.1142/S0129065718500120
Schaper, Frédéric L.W.V.J. ; Zhao, Yan ; Janssen, Marcus L.F. ; Wagner, G. Louis ; Colon, Albert J. ; Hilkman, Danny M.W. ; Gommer, Erik ; Vlooswijk, Mariëlle C.G. ; Hoogland, Govert ; Ackermans, Linda ; Bour, Lo J. ; Van Wezel, Richard J.A. ; Boon, Paul ; Temel, Yasin ; Heida, Tjitske ; Van Kranen-Mastenbroek, Vivianne H.J.M. ; Rouhl, Rob P.W. / Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy. In: International journal of neural systems. 2018.
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Schaper, FLWVJ, Zhao, Y, Janssen, MLF, Wagner, GL, Colon, AJ, Hilkman, DMW, Gommer, E, Vlooswijk, MCG, Hoogland, G, Ackermans, L, Bour, LJ, Van Wezel, RJA, Boon, P, Temel, Y, Heida, T, Van Kranen-Mastenbroek, VHJM & Rouhl, RPW 2018, 'Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy' International journal of neural systems. https://doi.org/10.1142/S0129065718500120

Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy. / Schaper, Frédéric L.W.V.J.; Zhao, Yan; Janssen, Marcus L.F.; Wagner, G. Louis; Colon, Albert J.; Hilkman, Danny M.W.; Gommer, Erik; Vlooswijk, Mariëlle C.G.; Hoogland, Govert; Ackermans, Linda; Bour, Lo J.; Van Wezel, Richard J.A.; Boon, Paul; Temel, Yasin; Heida, Tjitske; Van Kranen-Mastenbroek, Vivianne H.J.M.; Rouhl, Rob P.W. (Corresponding Author).

In: International journal of neural systems, 16.05.2018.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy

AU - Schaper, Frédéric L.W.V.J.

AU - Zhao, Yan

AU - Janssen, Marcus L.F.

AU - Wagner, G. Louis

AU - Colon, Albert J.

AU - Hilkman, Danny M.W.

AU - Gommer, Erik

AU - Vlooswijk, Mariëlle C.G.

AU - Hoogland, Govert

AU - Ackermans, Linda

AU - Bour, Lo J.

AU - Van Wezel, Richard J.A.

AU - Boon, Paul

AU - Temel, Yasin

AU - Heida, Tjitske

AU - Van Kranen-Mastenbroek, Vivianne H.J.M.

AU - Rouhl, Rob P.W.

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N2 - Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a promising treatment for patients with refractory epilepsy. However, therapy response varies and precise positioning of the DBS lead is potentially essential for maximizing therapeutic efficacy. We investigate if single-cell recordings acquired by microelectrode recordings can aid targeting of the ANT during surgery and hypothesize that the neuronal firing properties of the target region relate to clinical outcome. We prospectively included 10 refractory epilepsy patients and performed microelectrode recordings under general anesthesia to identify the change in neuronal signals when approaching and transecting the ANT. The neuronal firing properties of the target region, anatomical locations of microelectrode recordings and active contact positions of the DBS lead along the recorded trajectory were compared between responders and nonresponders to DBS. We obtained 19 sets of recordings from 10 patients (five responders and five nonresponders). Amongst the 403 neurons detected, 365 (90.6%) were classified as bursty. Entry into the ANT was characterized by an increase in firing rate while exit of the ANT was characterized by a decrease in firing rate. Comparing the trajectories of responders to nonresponders, we found differences neither in the neuronal firing properties themselves nor in their locations relative to the position of the active contact. Single-cell firing rate acquired by microelectrode recordings under general anesthesia can thus aid targeting of the ANT during surgery, but is not related to clinical outcome in DBS for patients with refractory epilepsy.

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