TY - JOUR
T1 - Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging
AU - Kröger, A. Pia P.
AU - Paulusse, Jos M.J.
N1 - Elsevier deal
PY - 2018/9/28
Y1 - 2018/9/28
N2 - As a relatively new class of materials, single-chain polymer nanoparticles (SCNPs) just entered the field of (biomedical) applications, with recent advances in polymer science enabling the formation of bio-inspired nanosized architectures. Exclusive intramolecular collapse of individual polymer chains results in individual nanoparticles. With sizes an order of magnitude smaller than conventional polymer nanoparticles, SCNPs are in the size regime of many proteins and viruses (1–20 nm). Multifaceted syntheses and design strategies give access to a wide set of highly modular SCNP materials. This review describes how SCNPs have been rendered water-soluble and highlights ongoing research efforts towards biocompatible SCNPs with tunable properties for controlled drug delivery, targeted imaging and protein mimicry.
AB - As a relatively new class of materials, single-chain polymer nanoparticles (SCNPs) just entered the field of (biomedical) applications, with recent advances in polymer science enabling the formation of bio-inspired nanosized architectures. Exclusive intramolecular collapse of individual polymer chains results in individual nanoparticles. With sizes an order of magnitude smaller than conventional polymer nanoparticles, SCNPs are in the size regime of many proteins and viruses (1–20 nm). Multifaceted syntheses and design strategies give access to a wide set of highly modular SCNP materials. This review describes how SCNPs have been rendered water-soluble and highlights ongoing research efforts towards biocompatible SCNPs with tunable properties for controlled drug delivery, targeted imaging and protein mimicry.
KW - UT-Hybrid-D
KW - Controlled drug delivery
KW - Intramolecular cross-linking
KW - Single chain polymer nanoparticles
KW - Targeted imaging
KW - Biomedical applications
UR - http://www.scopus.com/inward/record.url?scp=85051141769&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2018.07.041
DO - 10.1016/j.jconrel.2018.07.041
M3 - Article
AN - SCOPUS:85051141769
VL - 286
SP - 326
EP - 347
JO - Journal of controlled release
JF - Journal of controlled release
SN - 0168-3659
ER -