Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging

A. Pia P. Kröger; Jos M.J. Paulusse

doi:10.1016/j.jconrel.2018.07.041

Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging

A. Pia P. Kröger, Jos M.J. Paulusse^* (Corresponding Author)

^*Corresponding author for this work

Biomolecular Nanotechnology

Research output: Contribution to journal › Article › Academic › peer-review

39 Citations (Scopus)

74 Downloads (Pure)

Abstract

As a relatively new class of materials, single-chain polymer nanoparticles (SCNPs) just entered the field of (biomedical) applications, with recent advances in polymer science enabling the formation of bio-inspired nanosized architectures. Exclusive intramolecular collapse of individual polymer chains results in individual nanoparticles. With sizes an order of magnitude smaller than conventional polymer nanoparticles, SCNPs are in the size regime of many proteins and viruses (1–20 nm). Multifaceted syntheses and design strategies give access to a wide set of highly modular SCNP materials. This review describes how SCNPs have been rendered water-soluble and highlights ongoing research efforts towards biocompatible SCNPs with tunable properties for controlled drug delivery, targeted imaging and protein mimicry.

Original language	English
Pages (from-to)	326-347
Number of pages	22
Journal	Journal of controlled release
Volume	286
DOIs	https://doi.org/10.1016/j.jconrel.2018.07.041
Publication status	Published - 28 Sep 2018

Keywords

UT-Hybrid-D
Controlled drug delivery
Intramolecular cross-linking
Single chain polymer nanoparticles
Targeted imaging
Biomedical applications

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Cite this

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