Single-molecule bioelectronics

Jacob K. Rosenstein, Serge G. Lemay, Kenneth L. Shepard*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)
17 Downloads (Pure)


Experimental techniques that interface single biomolecules directly with microelectronic systems are increasingly being used in a wide range of powerful applications, from fundamental studies of biomolecules to ultra-sensitive assays. In this study, we review several technologies that can perform electronic measurements of single molecules in solution: ion channels, nanopore sensors, carbon nanotube field-effect transistors, electron tunneling gaps, and redox cycling. We discuss the shared features among these techniques that enable them to resolve individual molecules, and discuss their limitations. Recordings from each of these methods all rely on similar electronic instrumentation, and we discuss the relevant circuit implementations and potential for scaling these single-molecule bioelectronic interfaces to high-throughput arrayed sensing platforms.

Original languageEnglish
Pages (from-to)475-493
Number of pages19
JournalWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
Issue number4
Publication statusPublished - 1 Jul 2015


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