Single molecule detection on the cell membrane with Near-field Scanning Optical Microscopy

B.I. de Bakker

Research output: ThesisPhD Thesis - Research UT, graduation UT

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In this research we have developed a dedicated near- field scanning optical microscope (NSOM) for molecular biology and applied it to study the spatial organization of (fluorescently labeled) proteins at the cell surface. For the first time, protein clusters and individual molecules are resolved at the cell membrane with nanometer resolution using an optical method
Original languageUndefined
  • van Hulst, N.F., Supervisor
  • Garcia Parajo, M.F., Advisor
Award date19 Mar 2004
Place of PublicationEnschede, Netherlands
Print ISBNs90-365-2019-3
Publication statusPublished - 19 Mar 2004


  • IR-41416
  • METIS-218391

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