Single molecule detection on the cell membrane with Near-field Scanning Optical Microscopy

B.I. de Bakker

Single molecule detection on the cell membrane with Near-field Scanning Optical Microscopy

B.I. de Bakker

Optical Sciences

Research output: Thesis › PhD Thesis - Research UT, graduation UT

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Abstract

In this research we have developed a dedicated near- field scanning optical microscope (NSOM) for molecular biology and applied it to study the spatial organization of (fluorescently labeled) proteins at the cell surface. For the first time, protein clusters and individual molecules are resolved at the cell membrane with nanometer resolution using an optical method

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Twente
Supervisors/Advisors	van Hulst, N.F., Supervisor Garcia Parajo, M.F., Advisor
Award date	19 Mar 2004
Place of Publication	Enschede, Netherlands
Publisher	University of Twente
Print ISBNs	90-365-2019-3
Publication status	Published - 19 Mar 2004

Keywords

IR-41416
METIS-218391

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title = "Single molecule detection on the cell membrane with Near-field Scanning Optical Microscopy",

abstract = "In this research we have developed a dedicated near- field scanning optical microscope (NSOM) for molecular biology and applied it to study the spatial organization of (fluorescently labeled) proteins at the cell surface. For the first time, protein clusters and individual molecules are resolved at the cell membrane with nanometer resolution using an optical method",

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TY - THES

T1 - Single molecule detection on the cell membrane with Near-field Scanning Optical Microscopy

AU - de Bakker, B.I.

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AB - In this research we have developed a dedicated near- field scanning optical microscope (NSOM) for molecular biology and applied it to study the spatial organization of (fluorescently labeled) proteins at the cell surface. For the first time, protein clusters and individual molecules are resolved at the cell membrane with nanometer resolution using an optical method

KW - IR-41416

KW - METIS-218391

M3 - PhD Thesis - Research UT, graduation UT

SN - 90-365-2019-3

PB - University of Twente

CY - Enschede, Netherlands

ER -

Single molecule detection on the cell membrane with Near-field Scanning Optical Microscopy

Abstract

Keywords

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