Single neuron dynamics during experimentally induced anoxic depolarization

B. Zandt, Tyler Stigen, Bernard ten Haken, Theoden Netoff, Michel Johannes Antonius Maria van Putten

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
1 Downloads (Pure)


We studied single neuron dynamics during anoxic depolarizations, which are often observed in cases of neuronal energy depletion. Anoxic and similar depolarizations play an important role in several pathologies, notably stroke, migraine, and epilepsy. One of the effects of energy depletion was experimentally simulated in slices of rat cortex by blocking the sodium-potassium pumps with ouabain. The membrane voltage of pyramidal cells was measured. Five different kinds of dynamical behavior of the membrane voltage were observed during the resulting depolarizations. Using bifurcation analysis of a single cell model, we show that these voltage dynamics all are responses of the same cell, with normally functioning ion channels, to particular courses of the intra- and extracellular concentrations of sodium and potassium. © 2013 the American Physiological Society.
Original languageEnglish
Pages (from-to)1469-1475
JournalJournal of neurophysiology
Issue number7
Publication statusPublished - 2013


  • METIS-298469
  • IR-89388


Dive into the research topics of 'Single neuron dynamics during experimentally induced anoxic depolarization'. Together they form a unique fingerprint.

Cite this