@article{dc6899cd0de541ae859371dd0014b2f2,
title = "Single-step chitosan functionalized membranes for heparinization",
abstract = "Hemodialysis is an established life-sustaining treatment for blood purification. However, the limited hemocompatibility of the applied dialysis membranes makes additional heparin dosing to the patient inevitable. This work presents facile methods using chitosan for successful heparinization of membranes. First, a chitosan coating on commercial dialysis membranes and subsequent heparinization is shown. The resulting membranes exhibit significant charge differences and a considerable increase in pure water permeance. To overcome time-consuming and multi-step coating procedures, we demonstrate the single-step fabrication of promising chitosan-blended flat sheet and hollow fiber membranes. Highlights of these membranes are their significant surface charge differences, strong antifouling properties and their excellent hemocompatibility, which thrombin–antithrombin complex, complement and platelet activation measurements show. Furthermore, the heparinized surface increases the pure water permeance of the chitosan-blended membranes. The highly promising results of the heparinized chitosan-blended membranes enable their use in hemodialysis. Overall, the chitosan-blended membranes present another example in which single-step fabrication successfully replaces complex multi-step coating procedures.",
keywords = "Chitosan, Dialysis membrane, Heparinization, Membrane functionalization, Single-step fabrication, n/a OA procedure",
author = "Rose, {Ilka I.} and Michael Kather and Hannah Roth and Hannah D{\"u}nkelberg and Lukas Rein and Klimosch, {Sascha N.} and Manfred Schmolz and Matthias Wessling",
note = "Funding Information: This work was supported by the German Federal Ministry of Education and Research (BMBF) under the project “LTBC” ( FKZ: 13XP5075A-D ) and by the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation program ( 694946 ). M. Wessling appreciates the support from the Alexander-von-Humboldt foundation and the DFG funding through the Gottfried Wilhelm Leibniz Award 2019 ( WE 4678/12-1 ). This work was performed in part at the Center for Chemical Polymer Technology CPT, which is supported by the EU and the federal state of North Rhine-Westphalia (grant no. EFRE 30 00 883 02 ). The authors thank Karin Faensen taking for the excellent FeSEM images, Timo Linzenmeier for conducting the zeta potential measurements, and the LTBC project partners Baxter International and the Leibniz Institute for Polymer Research Dresden for the good collaboration and fruitful discussions. Funding Information: This work was supported by the German Federal Ministry of Education and Research (BMBF) under the project ?LTBC? (FKZ: 13XP5075A-D) and by the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation program (694946). M. Wessling appreciates the support from the Alexander-von-Humboldt foundation and the DFG funding through the Gottfried Wilhelm Leibniz Award 2019 (WE 4678/12-1). This work was performed in part at the Center for Chemical Polymer Technology CPT, which is supported by the EU and the federal state of North Rhine-Westphalia (grant no. EFRE 30 00 883 02). The authors thank Karin Faensen taking for the excellent FeSEM images, Timo Linzenmeier for conducting the zeta potential measurements, and the LTBC project partners Baxter International and the Leibniz Institute for Polymer Research Dresden for the good collaboration and fruitful discussions. Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",
year = "2022",
month = aug,
day = "5",
doi = "10.1016/j.memsci.2022.120567",
language = "English",
volume = "655",
journal = "Journal of membrane science",
issn = "0376-7388",
publisher = "Elsevier B.V.",
}