Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance

Seyed Mohammadali Dadfar; Denise Camozzi; Milita Darguzyte; Karolin Roemhild; Paola Varvarà; Josbert Metselaar; Srinivas Banala; Marcel Straub; Nihan Güvener; Ulrich Engelmann; Ioana Slabu; Miriam Buhl; Jan Van Leusen; Paul Kögerler; Benita Hermanns-Sachweh; Volkmar Schulz; Fabian Kiessling; Twan Lammers

doi:10.1186/s12951-020-0580-1

Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance

Seyed Mohammadali Dadfar, Denise Camozzi, Milita Darguzyte, Karolin Roemhild, Paola Varvarà, Josbert Metselaar, Srinivas Banala, Marcel Straub, Nihan Güvener, Ulrich Engelmann, Ioana Slabu, Miriam Buhl, Jan Van Leusen, Paul Kögerler, Benita Hermanns-Sachweh, Volkmar Schulz, Fabian Kiessling, Twan Lammers^*

^*Corresponding author for this work

Biomaterials Science and Technology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.[Figure not available: see fulltext.]

Original language	English
Article number	22
Journal	Journal of Nanobiotechnology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12951-020-0580-1
Publication status	Published - 28 Jan 2020

Keywords

Hyperthermia
Iron oxide nanoparticles
MPI
MRI
SPION

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Dadfar-2020-Size-isolation-of-superparamagneticFinal published version, 2.42 MBLicence: CC BY

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Dadfar, S. M., Camozzi, D., Darguzyte, M., Roemhild, K., Varvarà, P., Metselaar, J., Banala, S., Straub, M., Güvener, N., Engelmann, U., Slabu, I., Buhl, M., Van Leusen, J., Kögerler, P., Hermanns-Sachweh, B., Schulz, V., Kiessling, F., & Lammers, T. (2020). Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance. Journal of Nanobiotechnology, 18(1), Article 22. https://doi.org/10.1186/s12951-020-0580-1

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abstract = "Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist{\textregistered} and Sinerem{\textregistered}. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.[Figure not available: see fulltext.]",

keywords = "Hyperthermia, Iron oxide nanoparticles, MPI, MRI, SPION",

author = "Dadfar, {Seyed Mohammadali} and Denise Camozzi and Milita Darguzyte and Karolin Roemhild and Paola Varvar{\`a} and Josbert Metselaar and Srinivas Banala and Marcel Straub and Nihan G{\"u}vener and Ulrich Engelmann and Ioana Slabu and Miriam Buhl and {Van Leusen}, Jan and Paul K{\"o}gerler and Benita Hermanns-Sachweh and Volkmar Schulz and Fabian Kiessling and Twan Lammers",

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Dadfar, SM, Camozzi, D, Darguzyte, M, Roemhild, K, Varvarà, P, Metselaar, J, Banala, S, Straub, M, Güvener, N, Engelmann, U, Slabu, I, Buhl, M, Van Leusen, J, Kögerler, P, Hermanns-Sachweh, B, Schulz, V, Kiessling, F & Lammers, T 2020, 'Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance', Journal of Nanobiotechnology, vol. 18, no. 1, 22. https://doi.org/10.1186/s12951-020-0580-1

TY - JOUR

T1 - Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance

AU - Dadfar, Seyed Mohammadali

AU - Camozzi, Denise

AU - Darguzyte, Milita

AU - Roemhild, Karolin

AU - Varvarà, Paola

AU - Metselaar, Josbert

AU - Banala, Srinivas

AU - Straub, Marcel

AU - Güvener, Nihan

AU - Engelmann, Ulrich

AU - Slabu, Ioana

AU - Buhl, Miriam

AU - Van Leusen, Jan

AU - Kögerler, Paul

AU - Hermanns-Sachweh, Benita

AU - Schulz, Volkmar

AU - Kiessling, Fabian

AU - Lammers, Twan

PY - 2020/1/28

Y1 - 2020/1/28

N2 - Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.[Figure not available: see fulltext.]

AB - Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.[Figure not available: see fulltext.]

KW - Hyperthermia

KW - Iron oxide nanoparticles

KW - MPI

KW - MRI

KW - SPION

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C2 - 31992302

AN - SCOPUS:85078533410

SN - 1477-3155

VL - 18

JO - Journal of Nanobiotechnology

JF - Journal of Nanobiotechnology

IS - 1

M1 - 22

ER -

Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance

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