Slow electrical stimuli to affect connectivity in cultured neuronal networks

Jakob le Feber, J. Stegenga, Wim Rutten

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    Learning, or more generally, plasticity may be studied using cultured neuronal networks on multi electrode arrays. Many protocols have been proposed to change connectivity in such networks. One of these protocols, proposed by Shahaf and Marom, aimed to change the input-output relationship of a selected connection in a network. Although the results were quite promising, the experiments appeared difficult to repeat and the protocol did not serve as a basis for wider investigation yet. Here, we repeated their protocol, and compared our 'learning curves' to the original results. Although in some experiments the protocol did not seem to work, we found that on average, the protocol showed a significant learning effect indeed. Furthermore, the protocol always induces connectivity changes that were much larger than changes that occurred after a comparable period of random stimulation. Finally, our data suggest that network connectivity changes better induced using stimulation at a fixed, than using randomly changing electrodes.
    Original languageUndefined
    Title of host publicationProceeding of the 4th int IEEE EMBS Conf on Neural Engineering
    Place of PublicationPiscataway
    Number of pages4
    ISBN (Print)978-1-4244-2073-5
    Publication statusPublished - 29 Apr 2009
    Event4th International IEEE/EMBS Conference on Neural Engineering, NER 2009 - Antalya, Turkey
    Duration: 29 Apr 20092 May 2009
    Conference number: 4

    Publication series

    PublisherIEEE Computer Society Press


    Conference4th International IEEE/EMBS Conference on Neural Engineering, NER 2009
    Abbreviated titleNER


    • EWI-15366
    • METIS-265209
    • IR-62812
    • electrical stimuli connectivity cultured neuronal networks

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